Evidence map›Paper›PMID 33199590›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Allosteric modulation of alternatively spliced Ca

Woori Ko, Seung-Ryoung Jung, Kwon-Woo Kim, Jun-Hee Yeon, Cheon-Gyu Park, Joo Hyun Nam, Bertil Hille, Byung-Chang Suh

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Allosteric coupling between PIPProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. The plasma membrane inner leaflet PI(4,5)PNature communications · 2024
    Article
  6. Article
  7. Niclosamide potentiates TMEM16A and induces vasoconstriction.The Journal of general physiology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. CaInternational journal of molecular sciences · 2022
    Article
  13. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. Differential Regulation of CaInternational journal of molecular sciences · 2021
    Article
  17. CaMolecules and cells · 2021
    Article
  18. Review
  19. Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.Advances in experimental medicine and biology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Woori KoDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.ORCID 0000-0001-8271-6077
Seung-Ryoung JungDepartment of Physiology and Biophysics, University of Washington, Seattle, WA 98195.
Kwon-Woo KimDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.ORCID 0000-0003-0449-2172
Jun-Hee YeonDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
Cheon-Gyu ParkDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.ORCID 0000-0002-4739-1913
Joo Hyun NamDepartment of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.ORCID 0000-0001-8300-6974
Bertil HilleDepartment of Physiology and Biophysics, University of Washington, Seattle, WA 98195.ORCID 0000-0002-7266-1671
Byung-Chang SuhDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea; bcsuh@dgist.ac.kr.
Daegu Gyeongbuk Institute of Science and Technology · KRUniversity of Washington · USDongguk University · KR

Funding

Molecular Properties of Ionic Permeability in NerveR37NS008174 · NINDS · UNIVERSITY OF WASHINGTON · PI HILLE, BERTIL · 2013 to 2019
$3.8M
NINDS NIH HHS R37 NS008174
6 · The paper itself

Abstract

Transmembrane 16A (TMEM16A, anoctamin1), 1 of 10 TMEM16 family proteins, is a Cl

Indexed as

Alternative SplicingAllosteric RegulationAnimalsAnoctamin-1Binding SitesCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell MembraneGene Expression RegulationHEK293 CellsHumansIon Channel GatingMiceModels, MolecularMolecular ConformationMutagenesis, Site-DirectedPhosphatidylinositolsAnoctamin-1Calcium-Calmodulin-Dependent Protein Kinase Type 2PhosphatidylinositolsProtein IsoformsCa2+-activated Cl− channelintracellular ATPPI(4,5)P2splice variantsTMEM16A

Identifiers

PMID33199590
PMCPMC7720229
OpenAlexW3103341649

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.