Evidence map›Paper›PMID 33199639›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Lack of adipocyte purinergic P2Y

Shanu Jain, Sai P Pydi, Kiran S Toti, Bernard Robaye, Marco Idzko, Oksana Gavrilova, Jürgen Wess, Kenneth A Jacobson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Neutrophil-T cell cross talk in noninfectious liver diseases.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Review
  3. Applications of artificial intelligence in drug discovery for neurological diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Article
  5. Macrophage P2YActa pharmaceutica Sinica. B · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Knockout of Purinergic P2YInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Loss-of-function N178T variant of the human P2YFrontiers in pharmacology · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Shanu JainMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.ORCID 0000-0003-3110-1990
Sai P PydiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.ORCID 0000-0001-7170-6519
Kiran S TotiMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.ORCID 0000-0002-4528-4858
Bernard RobayeInstitute of Interdisciplinary Research (IRIBHM), Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Marco IdzkoUniversitätsklinik für Innere Medizin II, Klinische Abteilung für Pulmologie, Medizinische Universität, 1090 Vienna, Austria.
Oksana GavrilovaMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892; kennethj@niddk.nih.gov.ORCID 0000-0001-8104-1493
National Institute of Diabetes and Digestive and Kidney Diseases · USUniversité Libre de Bruxelles · BEUniversity Medical Center Freiburg · DE

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Development Of P2Y Receptor LigandsZIADK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$8.9M
Intramural NIH HHS ZIA DK031116Intramural NIH HHS ZIC DK070002NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255
6 · The paper itself

Abstract

Uridine diphosphate (UDP)-activated purinergic receptor P2Y

Indexed as

HomeostasisAdipocytesAdipose TissueAnimalsBiomarkersDiabetes Mellitus, Type 2Diet, High-FatDisease Models, AnimalEnergy MetabolismGene Expression RegulationGlucoseInflammationJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitochondriaBiomarkersGlucoseJNK Mitogen-Activated Protein Kinasespurinoceptor P2Y6Receptors, Purinergic P2adipocyteGPCRmetabolismnucleotidesobesity

Identifiers

PMID33199639
PMCPMC7720204
OpenAlexW3101979533

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.