Evidence map›Paper›PMID 33199783›Full record

ArticleScientific reports2020

Reconstitution of T follicular helper-humoral immune axis with elimination of hepatitis C virus.

Arshi Khanam, Shyamasundaran Kottilil, Eleanor Wilson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Hepatitis C virus modifiedJournal of virology · 2025
    Article
  3. Review
  4. Observational
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Arshi KhanamDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, School of Medicine, 725 West Lombard Street, S218, Baltimore, MD, 21201, USA.ORCID 0000-0001-6045-6884
Shyamasundaran KottililDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, School of Medicine, 725 West Lombard Street, S218, Baltimore, MD, 21201, USA.
Eleanor WilsonDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland, School of Medicine, 725 West Lombard Street, S218, Baltimore, MD, 21201, USA. Eleanor.wilson@ihv.umaryland.edu.
University of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exhaustion of Hepatitis C Virus (HCV)-specific T cells and abnormal B cell function is a hallmark of chronic HCV infection. Direct-acting antiviral (DAA) therapies are effective in achieving sustained virologic response (SVR), however, whether successful DAA treatment reconstitute T follicular helper (T

Indexed as

AdultAntiviral AgentsCase-Control StudiesClinical Trials, Phase II as TopicFemaleFollow-Up StudiesHepacivirusHepatitis CHumansImmunity, HumoralMaleMiddle AgedPrognosisRetrospective StudiesT-Lymphocytes, Helper-InducerAntiviral Agents

Identifiers

PMID33199783
PMCPMC7669852
OpenAlexW3103007576

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.