Evidence map›Paper›PMID 33200864›Full record

ArticleHIV medicine2021

Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV.

W M Han, A Jiamsakul, J Jantarapakde, E Yunihastuti, J Y Choi, R Ditangco, R Chaiwarith, L P Sun, S Khusuwan, T P Merati and 15 more

Open access · greenAbstract read
In one paragraph

Article in HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 13 countries.

W M HanThe Kirby Institute, UNSW, Sydney, NSW, Australia.ORCID 0000-0003-3731-7960
A JiamsakulThe Kirby Institute, UNSW, Sydney, NSW, Australia.ORCID 0000-0003-4810-0783
J JantarapakdeHIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
E YunihastutiFaculty of Medicine, Universitas Indonesia - Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
J Y ChoiDivision of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.ORCID 0000-0002-2775-3315
R DitangcoResearch Institute for Tropical Medicine, Muntinlupa City, Philippines.
R ChaiwarithResearch Institute for Health Sciences, Chiang Mai, Thailand.
L P SunNational Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia.
S KhusuwanChiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
T P MeratiFaculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia.
C D DoBach Mai Hospital, Hanoi, Vietnam.
I AzwaUniversity Malaya Medical Centre, Kuala Lumpur, Malaysia.
M-P LeeQueen Elizabeth Hospital, Hong Kong SAR, India.
K Van NguyenNational Hospital for Tropical Diseases, Hanoi, Vietnam.
Y-J ChanTaipei Veterans General Hospital, Taipei, Taiwan.
S KiertiburanakulFaculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
O T NgTan Tock Seng Hospital, Singapore, Singapore.
J TanumaNational Center for Global Health and Medicine, Tokyo, Japan.
S PujariInstitute of Infectious Diseases, Pune, India.ORCID 0000-0002-4571-650X
F ZhangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Y M GaniHospital Sungai Buloh, Sungai Buloh, Malaysia.
S SangleBJ Government Medical College and Sassoon General Hospital, Pune, India.
J RossTREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.ORCID 0000-0003-3183-2451
N KumarasamyChennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India.
the TREAT Asia HIV Observational Database (TAHOD) of IeDEA Asia-Pacific
UNSW Sydney · AUBạch Mai Hospital · VNB. J. Medical College & Sassoon Hospital · INCapital Medical University · CNChiangRai Prachanukroh Hospital · THHIV Netherlands Australia Thailand Research Collaboration · THHospital for Tropical Diseases · VNHospital Sungai Buloh · MYMahidol University · THNational Center for Global Health and Medicine · JPNational Center for HIV/AIDS, Dermatology and STD · KHQueen Elizabeth Hospital · CNResearch Institute for Tropical Medicine · PHSerum Institute of India (India) · INTaipei Veterans General Hospital · TWTan Tock Seng Hospital · SGUdayana University · IDUniversity Malaya Medical Centre · MYUniversity of Indonesia · IDVoluntary Health Services Hospital · IN

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

objectivesWe conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV).

methodsParticipants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds.

resultsOf 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m

conclusionsHigh pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort.

Indexed as

Anti-HIV AgentsCardiovascular DiseasesHIV InfectionsBody Mass IndexFemaleHumansMaleOverweightAnti-HIV Agentsbody mass indexcardiovascular risksHIVimmune recoveryvirological response

Identifiers

PMID33200864
PMCPMC8428815
OpenAlexW3099890798

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.