Evidence map›Paper›PMID 33205998›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2021

Musings on the wanderer: What's new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism.

Soledad Pitra, Bret N Smith

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Cell reports methods · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Glutamatergic plasticity within neurocircuits of the dorsal vagal complex and the regulation of gastric functions.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Soledad PitraDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky.
Bret N SmithDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky.
University of Kentucky · US

Funding

Neural Circuitry in the Dorsal Vagal ComplexR01DK056132 · NIDDK · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2001 to 2019
$4.9M
Diabetes, glucose metabolism, and neuroplasticity in the vagal complexR01DK122811 · NIDDK · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2020 to 2023
$1.9M
NMDA modulation of diabetes-induced glutamate synaptic plasticityR21HD079256 · NICHD · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2014 to 2015
$405k
HHS | NIH | National Institute of Child Health and Human Development (NICHD) R21HD079256HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK056132HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK122811NICHD NIH HHS R21 HD079256NIDDK NIH HHS R01 DK056132NIDDK NIH HHS R01 DK122811
6 · The paper itself

Abstract

Neurons in the brain stem dorsal vagal complex (DVC) take part in a continuous bidirectional crosstalk, in which they receive and respond to a vast array of signaling molecules, including glucose. Importantly, chronic dysregulation of blood glucose concentration, a hallmark of high prevalence pathologies, such as diabetes and metabolic syndrome, can induce neuroplasticity in DVC neural networks, which is hypothesized to either contribute to or compensate for the glycemic or insulinemic dysregulation observed in these conditions. Here, we revisit the topic of vagal reflexes to review recent research on the importance of DVC function in regulating systemic glucose homeostasis and the neuroplastic changes in this brain region that are associated with systemic glucose alterations. We also discuss the critical connection between these nuclei and the gut and the role of central vagal circuits in the favorable outcomes associated with bariatric surgical procedures for metabolic disorders.

Indexed as

AnimalsDigestive SystemGlucoseHumansNeuronsReflexVagus NerveGlucosediabetesdorsal motor nucleus of the vagusglucoseneuroplasticitynucleus tractus solitarius

Identifiers

PMID33205998
PMCPMC7938771
OpenAlexW3103752255

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.