ArticleNature communications2020
Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Disruption of Antioxidant Defense Systems in Honey Bees and Wild Bees Under Environmental Xenobiotic Pressure.Antioxidants (Basel, Switzerland) · 2026Review
- Deformed Wing Virus infection induces immunosuppression and gut dysbiosis in honey bees.Animal microbiome · 2026Article
- Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model.Scientific reports · 2025Article
- The Sublethal Effects of Neonicotinoids on Honeybees.Biology · 2025Review
- Oxidative stress biomarkers for assessing the synergistic toxicity of emamectin benzoate and cyantraniliprole on liver function.Scientific reports · 2025Article
- Avoiding the tragedies of parasite tolerance in Darwinian beekeeping.Proceedings. Biological sciences · 2025Review
- Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera).BMC biology · 2025Article
- Article
- Plastic pollution in agricultural landscapes: an overlooked threat to pollination, biocontrol and food security.Nature communications · 2024Review
- Article
- Mechanisms of Pathogen and Pesticide Resistance in Honey Bees.Physiology (Bethesda, Md.) · 2024Review
- Comprehensive Approach to PhenotypeInsects · 2024Article
- Effects of common co-occurring pesticides (a neonicotinoid and fungicide) on honey bee colony health in a semi-field study.Heliyon · 2024Article
- Neonicotinoid exposure increases Varroa destructor (Mesostigmata: Varroidae) mite parasitism severity in honey bee colonies and is not mitigated by increased colony genetic diversity.Journal of insect science (Online) · 2024Article
- Article
- The FungusMicroorganisms · 2023Article
- Expression of subunits of an insecticide target receptor varies across tissues, life stages, castes, and species of social bees.Molecular ecology · 2023Article
- Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances.Frontiers in physiology · 2023Article
- Fungivorous mites enhance the survivorship and development of stingless bees even when exposed to pesticides.Scientific reports · 2022Article
- Do pesticide and pathogen interactions drive wild bee declines?International journal for parasitology. Parasites and wildlife · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonicotinoid Clothianidin has a negative impact on NF-κB signaling and on immune responses controlled by this transcription factor, which can boost the proliferation of honey bee parasites and pathogens. This effect has been well documented for the replication of deformed wing virus (DWV) induced by Clothianidin in honey bees bearing an asymptomatic infection. Here, we conduct infestation experiments of treated bees to show that the immune-suppression exerted by Clothianidin is associated with an enhanced fertility of the parasitic mite Varroa destructor, as a possible consequence of a higher feeding efficiency. A conceptual model is proposed to describe the synergistic interactions among different stress agents acting on honey bees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.