Evidence map›Paper›PMID 33216350›Full record

Trial reportBritish journal of haematology2021

Kidney iron deposition by R2* is associated with haemolysis and urinary iron.

Christopher C Denton, Jon A Detterich, Thomas D Coates, John C Wood

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Impact of renal iron overload on sickle cell nephropathy in a humanized mouse model.American journal of physiology. Renal physiology · 2026
    Article
  2. Kidney R2* Mapping for Noninvasive Evaluation of Iron Overload in Paroxysmal Nocturnal Hemoglobinuria.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher C DentonDepartment of Pediatrics, Divisions of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3070-1775
Jon A DetterichDepartment of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2086-9569
Thomas D CoatesDepartment of Pediatrics, Divisions of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9878-6029
John C WoodDepartment of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0996-3439
University of Southern California · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Neuromodulatory Mechanisms and Regional Autonomic Dysregulation in the Development of Pain in Sickle Cell Disease PatientsU01HL117718 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COATES, THOMAS DUANE, KHOO, MICHAEL C K · 2013 to 2017
$9.6M
Childrens Hospital Los Angeles Child Health Research Development AwardK12HD052954 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WILLIAMS, ROBERTA GAY · 2006 to 2017
$4.0M
Cerebrovascular reserve and white matter disease in patients with anemiaR01HL136484 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2018 to 2021
$2.5M
Optimizing Tissue Iron Quantification at 3 TeslaR01DK097115 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2013 to 2016
$1.6M
Iron-mediated vascular disease in sickle cell disease.RC1HL099412 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2009 to 2010
$995k
Erythrocyte Nitric Oxide Links Rheology and Vasculopathy in Sickle Cell DiseaseK23HL119627 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI DETTERICH, JON A · 2014 to 2016
$497k
The Impact of Hemoglobin S on Red Blood Cell Nitric Oxide ProductionR03HL138321 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI DETTERICH, JON A · 2017 to 2018
$167k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCRR NIH HHS M01 RR000043NHLBI NIH HHS K12HD052954NHLBI NIH HHS K23 HL119627NHLBI NIH HHS K23HL119627NHLBI NIH HHS R01 HL136484NHLBI NIH HHS R01HL136484NHLBI NIH HHS R03 HL138321NHLBI NIH HHS R03HL138321NHLBI NIH HHS RC1 HL099412NHLBI NIH HHS U01 HL117718NICHD NIH HHS K12 HD052954NIDDK NIH HHS R01 DK097115
6 · The paper itself

Abstract

Kidney iron deposition measured by R2* (magnetic resonance imaging) MRI is posited to result from tubular reabsorption of filtered haemoglobin due to intravascular haemolysis. In chronically transfused sickle cell disease (SCD), R2* is elevated and positively correlated with lactate dehydrogenase (LDH). To account for contributions to renal iron from systemic iron overload, we evaluated kidney R2*, urinary iron and haemolysis markers in 62 non-transfused SCD patients. On multivariate analysis, kidney R2* was associated with urinary iron and LDH (R

Indexed as

Anemia, Sickle CellHemolysisKidneyKidney DiseasesMagnetic Resonance ImagingAdolescentAdultAgedBiomarkersChildFemaleHumansIronMaleMiddle AgedBiomarkersIron

Identifiers

PMID33216350
PMCPMC8084863
OpenAlexW3099232173

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.