Evidence map›Paper›PMID 33216667›Full record

Trial reportDiabetes technology & therapeutics2021

Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial.

Elvira Isganaitis, Dan Raghinaru, Louise Ambler-Osborn, Jordan E Pinsker, Bruce A Buckingham, R Paul Wadwa, Laya Ekhlaspour, Yogish C Kudva, Carol J Levy, Gregory P Forlenza and 6 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes technology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 5 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Early Stages of Automated Insulin Delivery.Diabetes technology & therapeutics · 2025
    Review
  20. Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Elvira IsganaitisResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Dan RaghinaruJaeb Center for Health Research, Tampa, Florida, USA.
Louise Ambler-OsbornResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Jordan E PinskerSansum Diabetes Research Institute, Santa Barbara, CA, USA.
Bruce A BuckinghamPediatric Endocrinology and Diabetes, Stanford Children's Health, Stanford, California, USA.
R Paul WadwaBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Laya EkhlaspourPediatric Endocrinology and Diabetes, Stanford Children's Health, Stanford, California, USA.
Yogish C KudvaDivision of Endocrinology, Diabetes, Metabolism, Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Carol J LevyDepartment of Medicine, Endocrinology, Diabetes and Bone Diseases, Mount Sinai Diabetes Center, New York, New York, USA.
Gregory P ForlenzaBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Roy W BeckJaeb Center for Health Research, Tampa, Florida, USA.
Craig KollmanJaeb Center for Health Research, Tampa, Florida, USA.
John W LumJaeb Center for Health Research, Tampa, Florida, USA.
Sue A BrownEndocrinology and Metabolism Division, Department of Medicine, Center for Diabetes Technology, University of Virginia, Charlottesville, Virginia, USA.
Lori M LaffelResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
iDCL Trial Research Group
Jaeb Center for Health Research · USJoslin Diabetes Center · USUniversity of Colorado Anschutz Medical Campus · USStanford Health Care · USDiabetes Australia · AUSansum Diabetes Research Institute · USUniversity of Virginia · USMayo Clinic · US

Funding

PROMOTING OPHTHALMIC SCREENING IN MANAGED CAREP60DK020541 · YESHIVA UNIVERSITY · 1986 to 2005
$12.6M
PILOT STUDY--SECRETORY TARGETING IN PANCREATIC B CELLSP30DK036836 · JOSLIN DIABETES CENTER · 1986 to 2025
$12.1M
PILOT AND FEASIBILITY (P/F) PROGRAMP30DK057521 · MASSACHUSETTS GENERAL HOSPITAL · 2000 to 2005
$8.2M
NYR-Diabetes Research Center (NYR-DRC)P30DK020541 · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2025 to 2025
$2.4M
NICHD NIH HHS R21 HD091974NIDDK NIH HHS K23 DK121942NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P60 DK020541NIDDK NIH HHS U24 DK123768NIDDK NIH HHS UC4 DK108483
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1AdolescentAdultGlycemic ControlHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsYoung AdultBlood GlucoseHypoglycemic AgentsInsulinAdolescentsClosed-loop control insulin deliveryTime in rangeYoung adult

Identifiers

PMID33216667
PMCPMC8080922
OpenAlexW3099316592

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.