Trial reportJournal of neurodevelopmental disorders2020
Telehealth-enabled behavioral treatment for problem behaviors in boys with fragile X syndrome: a randomized controlled trial.
Trial report in Journal of neurodevelopmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03510156 (Treatment of Disruptive Behaviors in Fragile X Syndrome), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Disruptive Behaviors in Fragile X Syndrome
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Telerehabilitation in children and adolescents with intellectual disability: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Behavioural and cognitive-behavioural interventions for outwardly directed aggressive behaviour in people with intellectual disabilities.The Cochrane database of systematic reviews · 2023Pooled it
- Caregiver Perspectives on Priorities and Barriers in Applied Behavior Analysis Service Delivery for Autistic Individuals: A Community-Engaged Sequential Mixed-Methods Study.Journal of autism and developmental disorders · 2026Article
- Adapting a Behavioral Intervention for Caregivers of Children with Down Syndrome or Fragile X Syndrome: A Pilot Study of RUBI-DD.Behavioral sciences (Basel, Switzerland) · 2026Article
- Impact of brief telehealth interventions on parental stress and challenging behaviors of children with fragile X syndrome.Orphanet journal of rare diseases · 2025Article
- The effect of anxiety and autism symptom severity on restricted and repetitive behaviors over time in children with fragile X syndrome.Journal of neurodevelopmental disorders · 2024Article
- The impact of social-environmental factors on IQ in syndromic intellectual developmental disabilities.Journal of clinical and translational science · 2024Review
- The Effect of Anxiety and Autism Symptom Severity on Restricted and Repetitive Behaviors Over Time in Children with Fragile X Syndrome.Research square · 2023Article
- Evaluation of telemental health services for people with intellectual and developmental disabilities: protocol for a randomized non-inferiority trial.BMC health services research · 2023Article
- Family and Caregiver Characteristics Contribute to Caregiver Change in Use of Strategies and Growth in Child Spoken Language in a Parent-Implemented Language Intervention in Fragile X Syndrome.Perspectives of the ASHA special interest groups · 2022Article
- Long-term follow-up of telehealth-enabled behavioral treatment for challenging behaviors in boys with fragile X syndrome.Journal of neurodevelopmental disorders · 2022Article
- Review
- Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC).Journal of neurodevelopmental disorders · 2022Article
- Applicability of the Guide for Monitoring Child Development as a Telehealth Delivered Intervention During the Pandemic.Frontiers in pediatrics · 2022Article
- Mental Health Challenges, Parenting Stress, and Features of the Couple Relationship in Parents of Children With Fragile X Syndrome.Frontiers in psychiatry · 2022Article
- Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data.Brain sciences · 2021Article
- Early Intervention Service Delivery via Telehealth During COVID-19: A Research-Practice Partnership.International journal of telerehabilitation · 2021Article
- Maternal Mental Health and Parenting Stress and Their Relationships to Characteristics of the Child With Fragile X Syndrome.Frontiers in psychiatry · 2021Article
- The effects of transition to technician-delivered telehealth ABA treatment during the COVID-19 crisis: A preliminary analysis.Journal of applied behavior analysis · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren with fragile X syndrome (FXS) are at increased risk for exhibiting problem behaviors such as aggression and self-injury. However, many children with FXS have limited access to behavioral treatments that have known efficacy due to the low availability of treatment providers and the wide geographical dispersion of families with FXS across the country. Telehealth may offer a cost-effective and practical solution to overcome these significant barriers. We examined the effect of administering an established behavior analytic intervention called functional communication training (FCT) via telehealth on levels of problem behaviors exhibited by boys with FXS. We also examined treatment acceptability, as well as the effect of the treatment on levels of parenting stress.
methodsBoys with FXS, aged 3 to 10 years, who displayed problem behaviors daily, were randomized to receive FCT via telehealth (n = 30) or treatment as usual (n = 27) over 12 weeks. Outcome measures included in-session observations of problem behavior, the Aberrant Behavior Checklist-Community (ABC-C), the Treatment Acceptability Rating Form-Revised (TARF-R), and the Parenting Stress Index, 4th edition (PSI-4).
resultsIntention-to-treat analyses indicated that scores on the irritability subscale of the ABC-C, our primary outcome measure, decreased significantly for boys who received FCT via telehealth compared to boys who received treatment as usual (p < .001, Cohen's d = 0.65). In-session observations conducted for those who received treatment showed that levels of problem behavior decreased by 91% from baseline. Levels of parenting stress related to child behavioral problems were also lower following FCT treatment, and caregivers reported that the intervention was acceptable.
conclusionsThese findings support telehealth-enabled FCT as a framework for expanding access to behavioral treatments for problem behaviors in children with FXS. Expanded delivery of behavior analytic treatment via telehealth also has the potential to lower healthcare costs, improve child and family quality of life, and lead to advances in the treatment of problem behavior in the broader population of individuals with neurodevelopmental disorders.
trial registrationClinicalTrials.gov, NCT03510156 . Registered 27 April 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.