Evidence map›Paper›PMID 33224579›Full record

ArticleAmerican journal of cardiovascular disease2020

Clinical safety and efficacy of World's thinnest (50 μm), very long (>40 mm) Everolimus Eluting Stent (SES) among real world patients.

Santosh Kumar Sinha, Mukesh Jitendra Jha, Vikas Mishra, Umeshwar Pandey, Mahmodullah Razi, Awadesh Kumar Sharma, Puneet Aggarwal, Ramesh Thakur, Vinay Krishna

Abstract read
In one paragraph

Article in American journal of cardiovascular disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Santosh Kumar SinhaDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Mukesh Jitendra JhaDepartment of Cardiology, Sri Aurobindo Institute of Medical Sciences Indore, MP, India.
Vikas MishraDepartment of Cardiology, Netaji Subhash Chandra Bose Medical College Jabalpur, MP, India.
Umeshwar PandeyDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Mahmodullah RaziDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Awadesh Kumar SharmaDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Puneet AggarwalDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Ramesh ThakurDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.
Vinay KrishnaDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSafety and efficacy of newer-generation and World's thinnest everolimus eluting stent (Evermine 50) in patients with very long and multiple lesions.

methodTotal of 711 patients received >40 mm long, World's thinnest (50 µm) Evermine 50 Everolimus eluting stent (Meril Life Sciences Pvt. Ltd., India) for various indications at LPS Institute of Cardiology, GSVM Medical College, Kanpur, UP, India between August 2017 and December 2018. Primary outcome as Device-oriented composite outcome (DOCO)- composite of cardiovascular death, target vessel myocardial infarction, and target lesion revascularization, secondary end points including peri-procedural device failure (failure of stent delivery, change of stent, edge dissection, stent fracture), target vessel failure (TVF), Global Cardiovascular End Points (GCEP)- composite of all-cause death, any MI, and any revascularization, and stent thrombosis (ST) were evaluated at 1-year follow-up.

resultMean age was 52.7±15.9 years and majority (78.6%) were male. Indications for implantation were STEMI (n=284; 46.2%), NSTEMI (n=201; 32.8%), UA (n=78; 12.6%), and CCS (n=52; 8.4%). Total of 989 lesions were treated among 711 patients. Median length of stent per lesion was 54±14 mm. DOCO occurred in 47 (6.6%) which was contributed by target vessel MI and TLR in 23 (3.2%) and 15 (2.1%) patients respectively. GCEP was observed in 117 (16.4%) at 12-month follow-up mainly attributed by any revascularization 60 (8.4%). Stent failure was seen in 36 (5.1%) patients mainly as result of failure of assigned stent delivery (n=18; 2.5%), and edge dissection (n=15; 2.1%). Definite and probable ST were observed in 8 (1.1%) and 6 (0.8%) patients respectively.

conclusionEvermine 50 Everolimus eluting stent is safe and effective to treat unduly long and multiple lesions.

Indexed as

device-oriented composite outcomeevermine 50global cardiovascular end pointsstent thrombosisUltrathin stent

Identifiers

PMID33224579
PMCPMC7675176

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.