Evidence map›Paper›PMID 33224775›Full record

ReviewCardiovascular diagnosis and therapy2020

Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.

Roberto J Bernardo, Francois Haddad, Etienne J Couture, Georg Hansmann, Vinicio A de Jesus Perez, André Y Denault, Frances S de Man, Myriam Amsallem

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular diagnosis and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 70 citations in OpenAlex.

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  14. Electrocardiographic markers predict hemodynamic parameters in adults with uncorrected secundum atrial septal defect.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Roberto J BernardoDivision of Pulmonary, Allergy and Critical Care, Stanford University School of Medicine, Stanford, CA, USA.
Francois HaddadVera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Etienne J CoutureDepartment of Anesthesiology, Quebec Heart and Lung Institute, Quebec, Canada.
Georg HansmannDepartment of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.
Vinicio A de Jesus PerezDivision of Pulmonary, Allergy and Critical Care, Stanford University School of Medicine, Stanford, CA, USA.
André Y DenaultDepartment of Anesthesiology and Division of Critical Care, Montreal Heart Institute, Université de Montréal, Montreal, Canada.
Frances S de ManAmsterdam University Medical Center, Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, PHEniX laboratory, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Myriam AmsallemVera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Stanford University · USCardiovascular Institute of the South · USMedizinische Hochschule Hannover · DEMontreal Heart Institute · CAUniversité de Montréal · CAVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right ventricular (RV) dysfunction is the most important determinant of survival in patients with pulmonary hypertension (PH). The manifestations of RV dysfunction not only include changes in global RV systolic function but also abnormalities in the pattern of contraction and synchrony. The effects of PH on the right ventricle have been mainly studied in patients with pulmonary arterial hypertension (PAH). However, with the demographic shift towards an aging population, heart failure with preserved ejection fraction (HFpEF) has become an important etiology of PH in recent years. There are significant differences in RV mechanics, function and adaptation between patients with PAH and HFpEF (with or without PH), which are related to different patterns of remodeling and dysfunction. Due to the unique features of the RV chamber, its connection with the main pulmonary artery and the pulmonary circulation, an understanding of the mechanics of RV function and its clinical significance is mandatory for both entities. In this review, we describe the mechanics of the pressure overloaded right ventricle. We review the different mechanical components of RV dysfunction and ventricular dyssynchrony, followed by insights via analysis of pressure-volume loop, energetics and novel blood flow patterns, such as vortex imaging. We conduct an in-depth comparison of prevalence and characteristics of RV dysfunction in HFpEF and PAH, and summarize key outcome studies. Finally, we provide a perspective on needed and expected future work in the field of RV mechanics.

Indexed as

Heart failure with preserved ejection fraction (HFpEF)mechanical efficiencypulmonary hypertension (PH)right ventricular dysfunction (RV dysfunction)ventriculo-arterial coupling

Identifiers

PMID33224775
PMCPMC7666917
OpenAlexW3036892765

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.