Evidence map›Paper›PMID 33225112›Full record

ArticleCurrent opinion in systems biology2020

Data integration for inferring context-specific gene regulatory networks.

Brittany Baur, Junha Shin, Shilu Zhang, Sushmita Roy

Abstract read
In one paragraph

Article in Current opinion in systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Network-based approaches for modeling disease regulation and progression.Computational and structural biotechnology journal · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brittany BaurWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Junha ShinWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Shilu ZhangWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Sushmita RoyWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
Computational Inference of Regulatory Network Dynamics on Cell LineagesR01GM117339 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ROY, SUSHMITA · 2016 to 2020
$1.5M
Computational approaches for comparative regulatory genomics to decipher long-range gene regulationR01HG010045 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI ROY, SUSHMITA · 2018 to 2021
$1.4M
NHGRI NIH HHS R01 HG010045NHGRI NIH HHS T32 HG002760NIGMS NIH HHS R01 GM117339
6 · The paper itself

Abstract

Transcriptional regulatory networks control context-specific gene expression patterns and play important roles in normal and disease processes. Advances in genomics are rapidly increasing our ability to measure different components of the regulation machinery at the single-cell and bulk population level. An important challenge is to combine different types of regulatory genomic measurements to construct a more complete picture of gene regulatory networks across different disease, environmental, and developmental contexts. In this review, we focus on recent computational methods that integrate regulatory genomic data sets to infer context specificity and dynamics in regulatory networks.

Indexed as

DataEnhancerGene regulatory networksGene regulationPromoterSingle cell

Identifiers

PMID33225112
PMCPMC7676633

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.