Evidence map›Paper›PMID 33225375›Full record

SynthesisJournal of rehabilitation medicine2021

Effectiveness of exercise interventions for children with cerebral palsy: A systematic review and meta-analysis of randomized controlled trials.

Xianrong Liang, Zhujiang Tan, Guojun Yun, Jianguo Cao, Jinggang Wang, Qing Liu, Turong Chen

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07683338 (Effect of Treadmill Gait Training Combined With Conventional Physiotherapy on Gait Performance and Functional Mobility in Children With Bilateral Spastic Cerebral Palsy), which is not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07683338 nacompletednot on this mapstarted 2026, after this paper: background citation

Effect of Treadmill Gait Training Combined With Conventional Physiotherapy on Gait Performance and Functional Mobility in Children With Bilateral Spastic Cerebral Palsy: A Randomized Controlled Trial

TypeinterventionalSponsorSyeda Khatoon e Jannat Welfare FoundationRan2026 to 2026Enrolled24ConditionsBilateral Spastic Cerebral Palsy, Cerebral Palsy, Spasticity Due to Cerebral Palsy, Gait AbnormalityArmsTreadmill Gait Training, Conventional Physiotherapy
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  3. Effects of various exercise interventions on motor function in cerebral palsy patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianrong LiangDepartment of Rehabilitation Medicine, Shenzhen children\'s Hospital, Shenzhen, China.
Zhujiang Tan
Guojun Yun
Jianguo Cao
Jinggang Wang
Qing Liu
Turong Chen
Shenzhen Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe results of previous research into exercise interventions for children with cerebral palsy are inconsistent. The aim of this study is to assess the effectiveness of such exercise interventions.

designSystematic review and meta-analysis.

methodsSystematic searches of the PubMed, Embase and Cochrane Library databases for randomized controlled trials involving exercise interventions for children with cerebral palsy, from inception to January 2020, were performed. Pooled weighted mean differences (WMDs) with 95% confidence intervals (95% CI) for gross motor function, gait speed, and muscle strength were calculated using random-effects models.

resultsA final total of 27 trials, including 834 children with cerebral palsy, were selected for quantitative analysis. Exercise interventions had no significant effect on the level of gross motor function (WMD 1.19; 95% CI -1.07 to 3.46; p  =  0.302). However, exercise interventions were associated with higher levels of gait speed (WMD 0.05; 95% CI 0.00-0.10; p  =  0.032) and muscle strength (WMD 0.92; 95% CI 0.19-1.64; p  =  0.013).

conclusionThese results suggest that exercise interventions may have beneficial effects on gait speed and muscle strength, but no significant effect on gross motor function in children with cerebral palsy.

Indexed as

AdolescentCerebral PalsyChildChild, PreschoolExercise TherapyHumansRandomized Controlled Trials as Topiccerebral palsychildexercisemeta-analysissystematic review

Identifiers

PMID33225375
PMCPMC8814858
OpenAlexW3109735734

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.