ReviewInternational journal of molecular sciences2020
Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses-A Presynaptic Perspective.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- L-DOPA Promotes Post-Treatment Neurovascular and Synaptic Homeostasis in Early Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Article
- Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs.Journal of anatomy · 2026Article
- L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina.bioRxiv : the preprint server for biology · 2026Article
- Dynamic structural plasticity facilitates the developmental assembly of cochlear inner hair cell ribbon synapses.Frontiers in cell and developmental biology · 2026Article
- Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses.Frontiers in synaptic neuroscience · 2026Article
- A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla.The Journal of comparative neurology · 2025Article
- The Plus End-Directed Microtubule (Kinesin-3 Family) Motor Protein KIF13B Is Associated with the Photoreceptor Synaptic Ribbon Complex.International journal of molecular sciences · 2025Article
- Development of the inner ear and regeneration of hair cells after hearing impairment.Fundamental research · 2025Review
- Biomolecular condensates and disease pathogenesis.Science China. Life sciences · 2024Review
- Electron Microscopic Mapping of Mitochondrial Morphology in the Cochlear Nerve Fibers.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea.iScience · 2024Article
- Article
- Age-dependent structural reorganization of utricular ribbon synapses.Frontiers in cell and developmental biology · 2023Article
- Fullerene Rosette: Two-Dimensional Interactive Nanoarchitectonics and Selective Vapor Sensing.International journal of molecular sciences · 2022Article
- Review
- Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.eLife · 2021Article
- Photoreceptor Compartment-Specific TULP1 Interactomes.International journal of molecular sciences · 2021Article
- Cannabinoid Signaling in Auditory Function and Development.Frontiers in molecular neuroscience · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the mammalian cochlea, specialized ribbon-type synapses between sensory inner hair cells (IHCs) and postsynaptic spiral ganglion neurons ensure the temporal precision and indefatigability of synaptic sound encoding. These high-through-put synapses are presynaptically characterized by an electron-dense projection-the synaptic ribbon-which provides structural scaffolding and tethers a large pool of synaptic vesicles. While advances have been made in recent years in deciphering the molecular anatomy and function of these specialized active zones, the developmental assembly of this presynaptic interaction hub remains largely elusive. In this review, we discuss the dynamic nature of IHC (pre-) synaptogenesis and highlight molecular key players as well as the transport pathways underlying this process. Since developmental assembly appears to be a highly dynamic process, we further ask if this structural plasticity might be maintained into adulthood, how this may influence the functional properties of a given IHC synapse and how such plasticity could be regulated on the molecular level. To do so, we take a closer look at other ribbon-bearing systems, such as retinal photoreceptors and pinealocytes and aim to infer conserved mechanisms that may mediate these phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.