Evidence map›Paper›PMID 33229294›Full record

ArticleAmerican heart journal2021

Adherence with lipid screening guidelines in standard- and high-risk children and adolescents.

Justin H Berger, Feiyan Chen, Jennifer A Faerber, Michael L O'Byrne, Julie A Brothers

Abstract read
In one paragraph

Article in American heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Adherence to Pediatric Screening.Journal of the American Heart Association · 2024
    Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Algorithms for Treating Dyslipidemia in Youth.Current atherosclerosis reports · 2023
    Review
  13. Observational
  14. Article
  15. Observational
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin H BergerDivision of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address: bergerj@email.chop.edu.
Feiyan ChenHealthcare Analytics Unit, The Children's Hospital of Philadelphia, Philadelphia, PA.
Jennifer A FaerberHealthcare Analytics Unit, The Children's Hospital of Philadelphia, Philadelphia, PA.
Michael L O'ByrneDivision of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA; Leonard Davis Institute for Health Economics and Center for Cardiovascular Outcomes, Quality, and Evaluative Research, University of Pennsylvania, Philadelphia, PA.
Julie A BrothersDivision of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Outcomes in Children Undergoing Cardiac CatheterizationK23HL130420 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI O'BYRNE, MICHAEL L · 2016 to 2020
$907k
NHLBI NIH HHS K23 HL130420NHLBI NIH HHS T32 HL007915
6 · The paper itself

Abstract

Because atherosclerosis begins in childhood, universal lipid screening is recommended with special attention to conditions predisposing to early atherosclerosis. Data about real-world penetration of these guidelines is not available.

methodsRetrospective cohort study using MarketScan® commercial and Medicaid insurance claims databases, a geographically representative sample of U.S. children. Subjects who passed through the 9- to 11-year window and had continuous insurance coverage between 1/1/2013 and 12/31/2016 were studied. Multivariable models were calculated, evaluating the association between other patient factors and the likelihood of screening. The primary hypothesis was that screening rates would be low, but that high-risk conditions would be associated with a higher likelihood of screening.

resultsIn total, 572,522 children (51% male, 33% black, 11% Hispanic, 51% Medicaid) were studied. The prevalence of high-risk conditions was 2.2%. In unadjusted and adjusted analyses, these subjects were more likely to be screened than standard-risk subjects (47% vs. 20%, OR: 3.7, 95% CI 3.5-3.8, P < .001). Within this group, the diagnosis-specific likelihood of screening varied (26-69%). Endocrinopathies (OR 5.4, 95% CI 5.2-5.7), solid organ transplants (OR 5.0, 95% CI 3.8-6.6), and metabolic disease (OR 3.9, 95% CI 3.1-5.0, all P < .001) were associated with the highest likelihood of undergoing screening.

conclusionsDespite national recommendations, lipid screening was performed in a minority of children. Though subjects with high-risk conditions had a higher likelihood of screening, rates remained low. This study highlights the need for research and advocacy regarding obstacles to lipid screening of children in the United States.

Indexed as

Organ TransplantationAntineoplastic AgentsAutoimmune DiseasesChildCohort StudiesDiabetes MellitusDyslipidemiasEndocrine System DiseasesFemaleGuideline AdherenceHeart DiseasesHumansMaleMass ScreeningMetabolic DiseasesMetabolic SyndromeAntineoplastic Agents

Identifiers

PMID33229294
PMCPMC7854880

What Socratic holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.