Evidence map›Paper›PMID 33232313›Full record

ReviewPLoS computational biology2020

Transforming the study of organisms: Phenomic data models and knowledge bases.

Anne E Thessen, Ramona L Walls, Lars Vogt, Jessica Singer, Robert Warren, Pier Luigi Buttigieg, James P Balhoff, Christopher J Mungall, Deborah L McGuinness, Brian J Stucky and 2 more

Abstract readReview
In one paragraph

Review in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The Ontology of Biological Attributes (OBA)-computational traits for the life sciences.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Article
  3. Article
  4. Pleiotropy data resource as a primer for investigating co-morbidities/multi-morbidities and their role in disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anne E ThessenEnvironmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America.ORCID 0000-0002-2908-3327
Ramona L WallsBio5 Institute, University of Arizona, Tucson, Arizona, United States of America.ORCID 0000-0001-8815-0078
Lars VogtTIB Leibniz Information Centre for Science and Technology, Hannover, Germany.ORCID 0000-0002-8280-0487
Jessica SingerAnnex Agriculture Inc., Saskatchewan, Canada.
Robert WarrenAnnex Agriculture Inc., Saskatchewan, Canada.
Pier Luigi ButtigiegAlfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven, Germany.ORCID 0000-0002-4366-3088
James P BalhoffRenaissance Computing Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Christopher J MungallEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.ORCID 0000-0002-6601-2165
Deborah L McGuinnessRensselaer Polytechnic Institute, Troy, New York, United States of America.ORCID 0000-0001-7037-4567
Brian J StuckyFlorida Museum of Natural History, University of Florida, Gainesville, Florida, United States of America.
Matthew J YoderIllinois Natural History Survey, Champaign, Illinois, United States of America.
Melissa A HaendelEnvironmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America.ORCID 0000-0001-9114-8737

Funding

Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2015 to 2025
$26.4M
The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Improvements to the LinkML framework to support the Phenomics First open science resourceRM1HG010860 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2020 to 2024
$10.3M
Forums for Integrative PhenomicsU13CA221044 · NCI · UNIVERSITY OF COLORADO DENVER · PI HAENDEL, MELISSA A, ROBINSON, PETER NICHOLAS · 2017 to 2019
$223k
NCI NIH HHS U13 CA221044NHGRI NIH HHS RM1 HG010860NIEHS NIH HHS U2C ES026555NIH HHS R24 OD011883
6 · The paper itself

Abstract

The rapidly decreasing cost of gene sequencing has resulted in a deluge of genomic data from across the tree of life; however, outside a few model organism databases, genomic data are limited in their scientific impact because they are not accompanied by computable phenomic data. The majority of phenomic data are contained in countless small, heterogeneous phenotypic data sets that are very difficult or impossible to integrate at scale because of variable formats, lack of digitization, and linguistic problems. One powerful solution is to represent phenotypic data using data models with precise, computable semantics, but adoption of semantic standards for representing phenotypic data has been slow, especially in biodiversity and ecology. Some phenotypic and trait data are available in a semantic language from knowledge bases, but these are often not interoperable. In this review, we will compare and contrast existing ontology and data models, focusing on nonhuman phenotypes and traits. We discuss barriers to integration of phenotypic data and make recommendations for developing an operationally useful, semantically interoperable phenotypic data ecosystem.

Indexed as

Databases, GeneticKnowledge BasesPhenomicsAnimalsClassificationComputational BiologyEcosystemGene-Environment InteractionHumansModels, BiologicalModels, GeneticModels, StatisticalPhenotypeSemantics

Identifiers

PMID33232313
PMCPMC7685442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.