Evidence map›Paper›PMID 33233678›Full record

ReviewCells2020

Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer's Disease.

Maria Calvo-Rodriguez, Elizabeth K Kharitonova, Brian J Bacskai

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Zolpidem restores sleep and decreases amyloid in a mouse model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Cystinosis and Cellular Energy Failure: Mitochondria at the Crossroads.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. ACognitive neurodynamics · 2024
    Article
  16. Article
  17. Astroglial activation: Current concepts and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria Calvo-RodriguezAlzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0001-6947-5547
Elizabeth K KharitonovaAlzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Brian J BacskaiAlzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Harvard University · US

Funding

Molecular pathways leading to neurodegeneration in vivoR01AG044263 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J · 2015 to 2019
$2.4M
Multiphoton microscopy for in vivo neural imagingR56AG060974 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J · 2019 to 2019
$598k
A replacement multiphoton microscope for in vivo imaging in rodent models of neurS10RR025645 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J · 2009 to 2009
$492k
NCRR NIH HHS S10 RR025645NIA NIH HHS R01 AG044263NIA NIH HHS R56 AG060974
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people worldwide. Unfortunately, none of the current treatments are effective at improving cognitive function in AD patients and, therefore, there is an urgent need for the development of new therapies that target the early cause(s) of AD. Intracellular calcium (Ca

Indexed as

Alzheimer DiseaseCalciumCalcium SignalingHomeostasisHumansCalciumAlzheimer’s diseaseamyloidcalcium homeostasisendoplasmic reticulumlysosomesmitochondriatautherapeutics

Identifiers

PMID33233678
PMCPMC7699688
OpenAlexW3103029239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.