ReviewGenes2020
The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals.
Review in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- One health considerations in veterinary palliative medicine.Veterinary and animal science · 2026Review
- Overweight and Obesity in Dogs and Cats: An Exploration of Animal Welfare and Behaviour Impacts, and Recommendations for Management in Veterinary Primary Care.Animals : an open access journal from MDPI · 2026Review
- Unraveling IGK locus in dog breeds: IMGTNAR genomics and bioinformatics · 2026Article
- Behavioural susceptibility to environmental influences in obesity- evidence from a companion animal model.BMC veterinary research · 2026Article
- Canine genome-wide association study identifiesScience (New York, N.Y.) · 2025Article
- Missense variants in MC4R gene are associated with obesity in cats.Veterinary research communications · 2025Article
- Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats.Frontiers in aging neuroscience · 2025Article
- Caregiver-reported increased food motivation and adiposity in dogs receiving antiseizure drugs.The Veterinary record · 2024Article
- Overweight and obesity in domestic cats: epidemiological risk factors and associated pathologies.Journal of feline medicine and surgery · 2024Review
- Evidence of obesity-induced inflammatory changes in client-owned cats.Veterinary world · 2024Article
- Examining the Potential Applicability of Orexigenic and Anorexigenic Peptides in Veterinary Medicine for the Management of Obesity in Companion Animals.Current issues in molecular biology · 2024Review
- Application of Next-Generation Sequencing (NGS) Techniques for Selected Companion Animals.Animals : an open access journal from MDPI · 2024Review
- Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model.Science advances · 2024Article
- Stress and the domestic cat: have humans accidentally created an animal mimic of neurodegeneration?Frontiers in neurology · 2024Review
- Sex Differences Associated with Weekend Catch-Up Sleep and Waist-to-Height-Ratio among South Korean Adults Using Korea National Health and Nutrition Examination Survey 2016-2021 Data.Healthcare (Basel, Switzerland) · 2023Article
- The development of interoceptive hunger signals.Developmental psychobiology · 2023Article
- Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years).Journal of cachexia, sarcopenia and muscle · 2023Article
- Effects of five carbohydrate sources on cat diet digestibility, postprandial glucose, insulin response, and gut microbiomes.Journal of animal science · 2023Article
- Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.Frontiers in genetics · 2023Article
- Role of Chemerin in Cardiovascular Diseases.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this review, we provide an overview of how genes link to obesity in humans, drawing on a wealth of information from laboratory animal models, and summarise the mechanisms by which obesity causes related disease. Throughout, we focus on how large-scale human studies and niche investigations of rare mutations in severely affected patients have improved our understanding of obesity biology and can inform our ability to interpret results of animal studies. For dogs, cats, and horses, we compare the similarities in obesity pathophysiology to humans and review the genetic studies that have been previously reported in those species. Finally, we discuss how veterinary genetics may learn from humans about studying precise, nuanced phenotypes and implementing large-scale studies, but also how veterinary studies may be able to look past clinical findings to mechanistic ones and demonstrate translational benefits to human research.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.