Evidence map›Paper›PMID 33233837›Full record

ArticleInternational journal of molecular sciences2020

Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning.

Melissa F Adasme, Sarah Naomi Bolz, Lauren Adelmann, Sebastian Salentin, V Joachim Haupt, Adriana Moreno-Rodríguez, Benjamín Nogueda-Torres, Verónica Castillo-Campos, Lilián Yepez-Mulia, José A De Fuentes-Vicente and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  8. Repurposing of rabeprazole as an anti-Journal of enzyme inhibition and medicinal chemistry · 2023
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  16. Structural binding site comparisons reveal Crizotinib as a novel LRRK2 inhibitor.Computational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Melissa F AdasmeBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0003-2217-4629
Sarah Naomi BolzBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0003-1943-0126
Lauren AdelmannBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.
Sebastian SalentinBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0003-0662-2209
V Joachim HauptBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.
Adriana Moreno-RodríguezFacultad de Ciencias Químicas, Universidad Autónoma Benito Juárez, Oaxaca 68120, Mexico.
Benjamín Nogueda-TorresDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Verónica Castillo-CamposDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Lilián Yepez-MuliaUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social, México City 06720, Mexico.ORCID 0000-0001-8675-5671
José A De Fuentes-VicenteLaboratorio de Investigación y Diagnóstico Molecular, Instituto de Ciencias Biológicas, Universidad de Ciencias y Artes de Chiapas. Libramiento Norte Poniente 1150, Col. Lajas Maciel, Tuxtla Gutiérrez 29029, Mexico.
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-9842-4167
Michael SchroederBiotechnology Center (BIOTEC), Technische Universität Dresden, 01307 Dresden, Germany.
Technische Universität Dresden · DEInstituto Politécnico Nacional · MXBenito Juárez Autonomous University of Oaxaca · MXMexican Social Security Institute · MXUniversidad de Ciencias y Artes de Chiapas · MX

Funding

Secretaría de Investigación y Posgrado del Instituto Politécnico Nacional 20200491
6 · The paper itself

Abstract

Chagas disease, caused by the parasite

Indexed as

CiprofloxacinDrug RepositioningFolic AcidNaproxenTrypanocidal AgentsAnimalsCell LineChagas DiseaseMiceStructure-Activity RelationshipTrypanosoma cruziCiprofloxacinFolic AcidNaproxenTrypanocidal AgentsChagasdrug repositioningnon-covalent interactionsstructural screeningTrypanosoma cruzi

Identifiers

PMID33233837
PMCPMC7699892
OpenAlexW3098888840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.