SynthesisJournal of athletic training2021
Exploring the Pain in Patellofemoral Pain: A Systematic Review and Meta-Analysis Examining Signs of Central Sensitization.
Synthesis in Journal of athletic training, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Effectiveness of local exercise therapy versus spinal manual therapy in patients with patellofemoral pain syndrome: medium term follow-up results of a randomized controlled trial.BMC musculoskeletal disorders · 2021Trial
- Cross-Cultural Adaptation and Validation of Knee Quality of Life 26-Item Questionnaire into Spanish in Patellofemoral Pain.Journal of clinical medicine · 2026Article
- [Idiopathic anterior knee pain-what is the problem?]Orthopadie (Heidelberg, Germany) · 2026Review
- Adolescent patellofemoral pain syndrome: reappraisal of pathophysiology and implications for clinical management.Orthopedic reviews · 2026Article
- Quantitative assessment of patellofemoral osteoarthritis via the pressure band test: an innovative and objective test.Quantitative imaging in medicine and surgery · 2025Article
- Pain is Modulated Differently Between Females With and Without Patellofemoral Pain: Factors Related to Sensitization.Journal of athletic training · 2025Article
- Influence of Pain, Risk Factors, and Functional Ability on Physical Activity Levels in Women with Anterior Knee Pain: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Quantitative Electroencephalography and Balance Test Correlations in Patients with Chronic Patellofemoral Pain.Journal of biomedical physics & engineering · 2024Article
- The association between conditioned pain modulation and psychological factors in people with chronic spinal pain: A systematic review.British journal of pain · 2024Article
- Article
- Central sensitization negatively influences the level of disability in female patients with anterior knee pain.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study.European radiology experimental · 2023Article
- Anterior Knee Pain: State of the Art.Sports medicine - open · 2022Review
- Efficacy and safety of duloxetine for postoperative pain after total knee arthroplasty in centrally sensitized patients: study protocol for a randomized controlled trial.BMC musculoskeletal disorders · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatellofemoral pain (PFP) has high recurrence rates and minimal long-term treatment success. Central sensitization refers to dysfunctional pain modulation that occurs when nociceptive neurons become hyperresponsive. Researchers in this area of PFP have been increasingly productive in the past decade.
objectiveTo determine whether evidence supports manifestations of central sensitization in individuals with PFP. DATA SOURCES: We searched MeSH terms for quantitative sensory testing (QST) pressure pain thresholds (PPTs), conditioned pain modulation (CPM), temporal summation, sensitization, hyperalgesia, and anterior knee pain or PFP in PubMed, SPORTDiscus, CINAHL, Academic Search Complete, and EBSCOhost. STUDY SELECTION: Peer-reviewed studies that were written in English and published between 2005 and 2020 and investigated QST or pain mapping in a sample with PFP were included in this review. DATA EXTRACTION: The initial search yielded 140 articles. After duplicates were removed, 78 abstracts were reviewed. The full text of 21 studies was examined, and we included 15 studies in our evaluation: 6 in the meta-analysis, 4 in the systematic review, and 5 in both the meta-analysis and systematic review. DATA SYNTHESIS: A random-effects meta-analysis was conducted for 4 QST variables (local PPTs, remote PPTs, CPM, temporal summation). Strong evidence supported lower local and remote PPTs, impaired CPM, and facilitated temporal summation in individuals with PFP compared with pain-free individuals. Evidence for heat and cold pain thresholds was conflicting. Pain mapping demonstrated expanding pain patterns associated with long duration of PFP symptoms.
conclusionsSigns of central sensitization were present in individuals with PFP, indicating altered pain modulation. The etiologic and treatment models of PFP should reflect the current body of evidence regarding central sensitization. Signs of central sensitization should be monitored clinically, and treatments with central effects should be considered as part of a multimodal plan of care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.