Evidence map›Paper›PMID 33238176›Full record

ArticleDiabetes research and clinical practice2021

Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium.

Leanne M Redman, Kimberly L Drews, Samuel Klein, Linda Van Horn, Rena R Wing, Xavier Pi-Sunyer, Mary Evans, Kaumudi Joshipura, S Sonia Arteaga, Alison G Cahill and 12 more

7 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01545934 nacompletednot on this map

Preventing Excessive Gestational Weight Gain in Obese Women

TypeinterventionalSponsorCalifornia Polytechnic State University-San Luis ObispoRan2012 to 2020Enrolled264ConditionsObesityArmsLifestyle intervention
NCT01610752 nacompletednot on this map

Expecting Success: Personalized Management of Body Weight During Pregnancy

TypeinterventionalSponsorPennington Biomedical Research CenterRan2012 to 2015Enrolled54ConditionsWeight Gain During PregnancyArmsSmartMoms
NCT01616147 nacompletednot on this map

LIFT: Lifestyle Interventions For Two (Member of the LIFE Moms Consortium)

TypeinterventionalSponsorColumbia UniversityRan2012 to 2017Enrolled210ConditionsOverweight, PregnancyArmsIntensive Lifestyle Intervention (ILI), Usual Care
NCT01631747 nacompletednot on this map

Maternal-Offspring Metabolics:Family Intervention Trial (MOMFIT)

TypeinterventionalSponsorNorthwestern UniversityRan2012 to 2017Enrolled281ConditionsPregnancy, Weight GainArmsLifestyle Intervention Group, Usual Care Group
NCT01768793 nacompletednot on this map

Weight Management in Obese Pregnant Underserved African American Women

TypeinterventionalSponsorWashington University School of MedicineRan2012 to 2017Enrolled267ConditionsObesity, Pregnancy, Weight GainArmsStandard Parents As Teachers (PAT), Parents As Teachers Plus (PAT+)
NCT01771133 naterminatednot on this map

Pregnancy and EARly Lifestyle Improvement Study

TypeinterventionalSponsorUniversity of Puerto RicoRan2013 to 2015Enrolled31ConditionsObesity, HyperglycemiaArmsLifestyle intervention group
NCT01812694 phase3completednot on this map

Lifestyle Interventions for Expectant Moms (LIFE-Moms) Phoenix

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2013 to 2017Enrolled123ConditionsObesity, Diet Therapy, Diabetes Type 2ArmsEnhanced standard care, Intensive lifestyle intervention
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. [A randomized controlled trial of weight management based on mobile health techno-logy among overweight or obese pregnant women].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Trial
  4. Article
  5. Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: leanne.redman@pbrc.edu.
Kimberly L DrewsThe Biostatistics Center, George Washington University, Washington, DC, USA.
Samuel KleinCenter for Human Nutrition, Washington University in St. Louis, St. Louis, MO, USA.
Linda Van HornDepartment of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Rena R WingDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Providence, RI, USA.
Xavier Pi-SunyerNew York Obesity Research Center, Dept. of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mary EvansNational Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, USA.
Kaumudi JoshipuraCenter for Clinical Research and Health Promotion, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico; Department of Epidemiology, Harvard T.H. Chan Public Health School, Harvard University, Boston, MA, USA.
S Sonia ArteagaDivision of Cardiovascular Diseases, The National Heart, Lung, and Blood Institute, Bethesda, MD, USA; The Environmental Influences on Child Health Outcomes (ECHO) Program Office, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Alison G CahillDepartment of Women's Health, Dell Medical School, The University of Texas at Austin, TX, USA.
Rebecca G CliftonThe Biostatistics Center, George Washington University, Washington, DC, USA.
Kimberly A CouchPhoenix Indian Medical Center, Indian Health Service, Phoenix, AZ, USA.
Paul W FranksDepartment of Nutrition, Harvard T.H. Chan Public Health School, Harvard University, Boston, MA, USA; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Dympna GallagherNew York Obesity Research Center, Dept. of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Debra Haire-JoshuCenter for Diabetes Translation Research, Washington University in St. Louis, St. Louis, MO, USA.
Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA, USA.
Alan M PeacemanDepartment of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Suzanne PhelanDepartment of Kinesiology, California Polytechnic State University, San Luis Obispo, CA, USA.
Elizabeth A ThomThe Biostatistics Center, George Washington University, Washington, DC, USA.
Susan Z YanovskiNational Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, USA.
William C KnowlerDiabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA.
LIFE-Moms Research Group

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR002345 · WASHINGTON UNIVERSITY · 2025 to 2025
$9.3M
RESEARCH TRAININGP30DK026687 · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · 1986 to 2025
$7.5M
Washington University Nutrition Obesity Research CenterP30DK056341 · WASHINGTON UNIVERSITY · 1999 to 2025
$5.7M
Capacity Advancement in Research InfrastructureS21MD001830 · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2005 to 2005
$5.0M
Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
The Washington University Center for Diabetes Translation ResearchP30DK092950 · WASHINGTON UNIVERSITY · 2025 to 2025
$850k
NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NHLBI NIH HHS U01 HL114344NHLBI NIH HHS U01 HL114377NICHD NIH HHS U01 HD072834NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30 DK092950NIDDK NIH HHS U01 DK094416NIDDK NIH HHS U01 DK094418NIDDK NIH HHS U01 DK094463NIDDK NIH HHS U01 DK094466NIGMS NIH HHS U54 GM104940NIMHD NIH HHS S21 MD001830NIMHD NIH HHS U54 MD007587
6 · The paper itself

Abstract

aimsTo examine the effect of lifestyle (diet and physical activity) interventions on the prevalence of GDM, considering the method of GDM ascertainment and its association with early pregnancy characteristics and maternal and neonatal outcomes in the LIFE-Moms consortium.

methodsLIFE-Moms evaluated the effects of lifestyle interventions to optimize gestational weight gain in 1148 pregnant women with BMI ≥ 25 kg/m

resultsLifestyle interventions initiated prior to 16 weeks reduced early excess GWG compared with standard care (0.35 ± 0.24 vs 0.43 ± 0.26 kg per week, p=<0.0001) but did not affect GDM diagnosis (11.1% vs 11.6%, p = 0.91). Using the 75-gram, 2-hour OGTT, 13. 0% of standard care and 11.0% of the intervention group had GDM by the IADPSG criteria (p = 0.45). The 'type of diagnostic test' did not change the result (p = 0.86). Women who developed GDM were significantly heavier, more likely to have obesity, and more likely to have dysglycemia at baseline.

conclusionModerate-to-high intensity lifestyle interventions grounded in behavior change theory initiated between 9 and 16-weeks gestation did not affect the prevalence of GDM despite reducing early GWG. CLINICALTRIALS.GOV: NCT01545934, NCT01616147, NCT01771133, NCT01631747, NCT01768793, NCT01610752, NCT01812694.

Indexed as

AdultDiabetes, GestationalFemaleGestational Weight GainHumansLife StyleObesityPregnancyClinical trialsGestational diabetes mellitusLifestyle modification

Identifiers

PMID33238176
PMCPMC9041868

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.