Evidence map›Paper›PMID 33238444›Full record

ReviewBiomolecules2020

Post-Myocardial Infarction Ventricular Remodeling Biomarkers-The Key Link between Pathophysiology and Clinic.

Maria-Madălina Bostan, Cristian Stătescu, Larisa Anghel, Ionela-Lăcrămioara Șerban, Elena Cojocaru, Radu Sascău

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

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  10. MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction.Cardiovascular & hematological agents in medicinal chemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Maria-Madălina BostanInternal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.
Cristian StătescuInternal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.ORCID 0000-0001-6439-4561
Larisa AnghelInternal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.
Ionela-Lăcrămioara ȘerbanPhysiology Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.
Elena CojocaruDepartment of Morphofunctional Sciences I-Pathology, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.ORCID 0000-0001-7859-840X
Radu SascăuInternal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iasi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies in recent years have shown increased interest in developing new methods of evaluation, but also in limiting post infarction ventricular remodeling, hoping to improve ventricular function and the further evolution of the patient. This is the point where biomarkers have proven effective in early detection of remodeling phenomena. There are six main processes that promote the remodeling and each of them has specific biomarkers that can be used in predicting the evolution (myocardial necrosis, neurohormonal activation, inflammatory reaction, hypertrophy and fibrosis, apoptosis, mixed processes). Some of the biomarkers such as creatine kinase-myocardial band (CK-MB), troponin, and N-terminal-pro type B natriuretic peptide (NT-proBNP) were so convincing that they immediately found their place in the post infarction patient evaluation protocol. Others that are related to more complex processes such as inflammatory biomarkers, atheroma plaque destabilization biomarkers, and microRNA are still being studied, but the results so far are promising. This article aims to review the markers used so far, but also the existing data on new markers that could be considered, taking into consideration the most important studies that have been conducted so far.

Indexed as

AnimalsApoptosisBiomarkersFibrosisHumansInflammationMicroRNAsMyocardial InfarctionNecrosisNeurotransmitter AgentsVentricular RemodelingBiomarkersMicroRNAsNeurotransmitter Agentsapoptosis biomarkersfibrosis biomarkersinflammatory reaction biomarkersmyocardial necrosis biomarkersneurohormonal activation biomarkersnew generation biomarkerspost-myocardial infarction ventricular remodelingprognosis

Identifiers

PMID33238444
PMCPMC7700609
OpenAlexW3107000709

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.