ArticleFrontiers in aging neuroscience2020
Brain Entropy Mapping in Healthy Aging and Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 80 citations in OpenAlex.
- Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study.Journal of neuroscience research · 2026Article
- Lifespan trajectories of the brain's functional complexity characterized by multiscale sample entropy.NeuroImage · 2026Article
- Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape.Aging cell · 2026Article
- Reduced but Reversible Brain Entropy After Occupational Partial Sleep Deprivation in Night-Shift Medical Staff.Brain and behavior · 2026Article
- The entropic view of aging: from thermodynamics to biology.Life medicine · 2026Article
- Aberrant Brain Entropy in Alzheimer's Disease: Evidence From a Resting-State fMRI Study.Brain and behavior · 2026Article
- Consistent Brain Entropy Changes During Rumination Across Three Magnetic Resonance Imaging Scanners.Neural plasticity · 2026Article
- Brain entropy as a biomarker of major depression in adolescents and young adults: insights from multimodal resting-state functional magentic resonance imaging.Psychoradiology · 2026Article
- Functional transition rate of the default mode network is associated with self-reported resilience.NeuroImage · 2025Article
- Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region.Translational psychiatry · 2025Article
- Alzheimer's disease classification using mutual information generated graph convolutional network for functional MRI.Journal of Alzheimer's disease : JAD · 2025Article
- Chronic pain is associated with greater brain entropy in the prefrontal cortex.The journal of pain · 2025Article
- Normative Brain Entropy Across the Lifespan.bioRxiv : the preprint server for biology · 2025Article
- Differences in brain function entropy due to cognitive impairment: Application of functional near infrared spectroscopy measures during dual-tasking.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Article
- Intra- and Inter-Regional Complexity in Multi-Channel Awake EEG Through Multivariate Multiscale Dispersion Entropy for Assessing Sleep Quality and Aging.Biosensors · 2025Article
- The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Electroencephalogram-based time-frequency analysis for Alzheimer's disease detection using machine learning.Journal of biological methods · 2025Article
- Resting state fMRI-based temporal coherence mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.BMC neuroscience · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its functional integrity, likely creating or maintaining a big "reserve" to counteract the high entropy. Malfunctions of this latent reserve may indicate a critical point of disease progression. The purpose of this study was to characterize BEN in aging and AD and to test an inverse-U-shape BEN model: BEN increases with age and AD pathology in normal aging but decreases in the AD continuum. BEN was measured with resting state fMRI and compared across aging and the AD continuum. Associations of BEN with age, education, clinical symptoms, and pathology were examined by multiple regression. The analysis results highlighted resting BEN in the default mode network, medial temporal lobe, and prefrontal cortex and showed that: (1) BEN increased with age and pathological deposition in normal aging but decreased with age and pathological deposition in the AD continuum; (2) AD showed catastrophic BEN reduction, which was related to more severe cognitive impairment and daily function disability; and (3) BEN decreased with education years in normal aging, but not in the AD continuum. BEN evolution follows an inverse-U trajectory when AD progresses from normal aging to AD dementia. Education is beneficial for suppressing the entropy increase potency in normal aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.