Evidence map›Paper›PMID 33243209›Full record

Trial reportBMC women's health2020

The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia.

Cezary Chojnacki, Marta Mędrek-Socha, Paulina Konrad, Jan Chojnacki, Aleksandra Błońska

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC women's health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04352062 (The Usefulness of Melatonin Supplementation in Postmenopausal Women With Helicobacter Pylori-associated Dyspepsia), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04352062 nacompletednot on this map

The Usefulness of Melatonin Supplementation in Postmenopausal Women With Helicobacter Pylori-associated Dyspepsia

TypeinterventionalSponsorMedical University of LodzRan2011 to 2018Enrolled152ConditionsMelatonin DeficiencyArmsMelatonin, placebo, Pantoprazole 40mg, Amoxicillin, Levofloxacin 500mg
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Is the Addition of Sublingual Melatonin to Omeprazole Superior to Omeprazole Alone in the Management of Gastroesophageal Reflux Disease Symptoms: A Clinical Trial.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Trial
  2. Review
  3. Therapeutic Potential of Melatonin in Functional Dyspepsia.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Article
  4. Article
  5. Melatonin as a Potential Multitherapeutic Agent.Journal of personalized medicine · 2021
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cezary ChojnackiDepartment of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland.
Marta Mędrek-SochaDepartment of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland.
Paulina KonradDepartment of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland.
Jan ChojnackiDepartment of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland.
Aleksandra BłońskaDepartment of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland. aleksandra.blonska@umed.lodz.pl.ORCID 0000-0001-6767-5780
Medical University of Lodz · PL

Funding

Krajowy Naukowy Osrodek Wiodacy RNN/596/11/KB
6 · The paper itself

Abstract

backgroundDyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.

methodsThe study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb).

resultsNo significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72 pg/ml) and Group II (10.5 ± 3.73 pg/ml; p > 0,05). The level was significantly lower in Group III (5.72 ± 1.42 pg/ml; p < 0.001). Eradication of H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p > 0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p < 0.001).

conclusionMelatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone.

trial registrationNCT04352062, date of registration: 15.04.2020.

Indexed as

Dietary SupplementsDyspepsiaHelicobacter InfectionsHelicobacter pyloriMelatoninAgedFemaleHumansMiddle AgedPostmenopauseTreatment OutcomeMelatoninDyspepsiaHelicobacter pyloriMelatoninMenopause

Identifiers

PMID33243209
PMCPMC7691069
OpenAlexW3107416592

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.