ArticleThe Journal of biological chemistry
A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.
Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Metabolomic Profiling ofJournal of fungi (Basel, Switzerland) · 2026Article
- Quiescence improvesbioRxiv : the preprint server for biology · 2026Article
- A new compound that extends the lifespan of worms, with favorableRSC medicinal chemistry · 2026Article
- Sphingolipid and methionine metabolism in aging.Journal of cell science · 2025Review
- Serine metabolism in aging and age-related diseases.GeroScience · 2025Review
- Increased alcohol dehydrogenase 1 activity promotes longevity.Current biology : CB · 2023Article
- One-carbon metabolic enzymes are regulated during cell division and make distinct contributions to the metabolome and cell cycle progression in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2023Article
- BY4741 cannot enter quiescence from rich medium.microPublication biology · 2023Article
- The contradictory role of branched-chain amino acids in lifespan and insulin resistance.Frontiers in nutrition · 2023Review
- Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.Aging cell · 2022Article
- Quiescence inAnnual review of genetics · 2022Review
- The Lipid Profile of theJournal of fungi (Basel, Switzerland) · 2022Article
- Ecological memory of prior nutrient exposure in the human gut microbiome.The ISME journal · 2022Article
- The Effect of Different Substrates on the Morphological Features and Polyols Production ofMicroorganisms · 2022Article
- A Microfluidic Platform for Tracking Individual Cell Dynamics during an Unperturbed Nutrients Exhaustion.Bio-protocol · 2022Article
- Review
- Histone H3 lysine 27 acetylation profile undergoes two global shifts in undernourished children and suggests altered one-carbon metabolism.Clinical epigenetics · 2021Article
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Caloric restriction (CR) improves health span and life span of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging-associated diseases. In budding yeast, Saccharomyces cerevisiae, CR is commonly defined by reduced glucose in the growth medium, which extends both replicative and chronological life span (CLS). We found that conditioned media collected from stationary-phase CR cultures extended CLS when supplemented into nonrestricted (NR) cultures, suggesting a potential cell-nonautonomous mechanism of CR-induced life span regulation. Chromatography and untargeted metabolomics of the conditioned media, as well as transcriptional responses associated with the longevity effect, pointed to specific amino acids enriched in the CR conditioned media (CRCM) as functional molecules, with L-serine being a particularly strong candidate. Indeed, supplementing L-serine into NR cultures extended CLS through a mechanism dependent on the one-carbon metabolism pathway, thus implicating this conserved and central metabolic hub in life span regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.