SynthesisEuropean journal of pediatrics2021
Heart rate variability as possible marker of brain damage in neonates with hypoxic ischemic encephalopathy: a systematic review.
Synthesis in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06744244 (Olfactory Memory in Infants With Signs of Asphyxia), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Olfactory Memory in Infants With Signs of Asphyxia: An Early Indicator of Neurodevelopmental Outcomes
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- CoolCuddle and Autonomic Regulation in Infants With Hypoxic-Ischaemic Encephalopathy: An Intervention Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Quantitative measures of autonomic cardiorespiratory maturation in preterm infants are associated with brain volumes at term age.Early human development · 2026Article
- Assessment of parasympathetic tone during therapeutic hypothermia in infants with brain injury following neonatal encephalopathy.Pediatric research · 2026Article
- Alpha-adrenergic mediated changes in blood pressure variability after hypoxia-ischaemia in preterm fetal sheep.The Journal of physiology · 2026Article
- Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning.Resuscitation · 2026Article
- Quantitative assessment of heart-brain coupling in neonates with hypoxic-ischemic encephalopathy.Frontiers in network physiology · 2026Article
- Day-2 echocardiography and cardiovascular biomarkers measurements in neonates with hypoxic-ischemic encephalopathy with or without brain injury.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Heart Rate Variability as a Predictor of Region-Specific Brain Injury in Neonates with Perinatal Asphyxia: A Prospective Study in a Middle-Income Country.Medicina (Kaunas, Lithuania) · 2025Observational
- Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review.Pediatric research · 2025Article
- Heart rate patterns predicting cerebral palsy in preterm infants.Pediatric research · 2025Article
- Fusion Model Using Resting Neurophysiological Data to Help Mass Screening of Methamphetamine Use Disorder.IEEE journal of translational engineering in health and medicine · 2025Article
- Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy.American journal of perinatology · 2024Article
- Impaired Brain-Heart Relation in Patients With Methamphetamine Use Disorder During VR Induction of Drug Cue Reactivity.IEEE journal of translational engineering in health and medicine · 2024Article
- Neonatal Seizure Detection Using a Wearable Multi-Sensor System.Bioengineering (Basel, Switzerland) · 2023Article
- Clinical applications of contactless photoplethysmography for vital signs monitoring in pediatrics: A systematic review and meta-analysis.Journal of clinical and translational science · 2023Review
- Optimal neuromonitoring techniques in neonates with hypoxic ischemic encephalopathy.Frontiers in pediatrics · 2023Review
- Hypothermia and heart rate variability in a healthy newborn piglet model.Scientific reports · 2022Article
- Splanchnic oxygen saturation during reoxygenation with 21% or 100% OPediatric research · 2022Article
- Associations between fetal heart rate variability and umbilical cord occlusions-induced neural injury: An experimental study in a fetal sheep model.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Heart Rate Variability Analysis for Seizure Detection in Neonatal Intensive Care Units.Bioengineering (Basel, Switzerland) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart rate variability (HRV) is currently considered the most valuable non-invasive test to investigate the autonomic nervous system function, based on the fact that fast fluctuations might specifically reflect changes of sympathetic and vagal activity. An association between abnormal values of HRV and brain impairment has been reported in the perinatal period, although data are still fragmentary. Considering such association, HRV has been suggested as a possible marker of brain damage also in case of hypoxic-ischemic encephalopathy following perinatal asphyxia. The aim of the present manuscript was to review systematically the current knowledge about the use of HRV as marker of cerebral injury in neonates suffering from hypoxic-ischemic encephalopathy. Findings reported in this paper were based on qualitative analysis of the reviewed data. Conclusion: A growing body of research supports the use of HRV as non-invasive, bedside tool for the monitoring of hypoxic-ischemic encephalopathy. The currently available data about the role of HRV as prognostic tool in case of hypoxic ischemic encephalopathy are promising but require further validation by future studies. What is Known: • Heart rate variability (HRV) is a non-invasive monitoring technique to assess the autonomic nervous system activity. • A correlation between abnormal HRV and cerebral injury has been reported in the perinatal period, and HRV has been suggested as possible marker of brain damage in case of hypoxic-ischemic encephalopathy. What is New: • HRV might provide precocious information about the entity of brain injury in asphyxiated neonates and be of help to design early, specific, and personalized treatments according to severity. • Further investigations are required to confirm these preliminary data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.