SynthesisThe lancet. Diabetes & endocrinology2021
Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature.
Synthesis in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025.Endocrine journal · 2026Guideline
- What should we focus on in pregnancy complicated by pheochromocytoma? a bibliometric analysis (1990-2024).Frontiers in oncology · 2025Pooled it
- Pheochromocytoma Across the Perioperative Course: Current Concepts and Clinical Management.Anesthesiology research and practice · 2026Review
- Paraganglioma in Pregnancy with Recurrent Pregnancy Loss: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2025Article
- Bladder paraganglioma in pregnancy with a successful perinatal outcome: a case report.BJR case reports · 2025Article
- Postpartum pheochromocytoma crisis associated with cardiogenic shock and Sheehan's syndrome.BMJ case reports · 2025Article
- Pheochromocytoma in MEN2.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Urinary bladder paraganglioma in pregnancy: a case report and literature review.Frontiers in medicine · 2025Article
- Article
- Management of Pheochromocytomas and Paragangliomas.The Surgical clinics of North America · 2024Review
- Inferior Laryngeal Nerve Paraganglioma With Norepinephrine Hypersecretion Diagnosed Shortly After Pregnancy.JCEM case reports · 2024Article
- Successful delivery in the setting of SDHB metastatic paraganglioma.Endocrinology, diabetes & metabolism case reports · 2024Article
- An Unusual Case of Pheochromocytoma Associated with von Hippel-Lindau Disease and Lynch Syndrome During Pregnancy.JCEM case reports · 2024Article
- A rare case of pheochromocytoma in a pregnant woman presenting with chest pain: extraordinary management.BMC cardiovascular disorders · 2024Article
- Maternal pheochromocytoma and childbirth in Sweden 1973-2015: a population-based study on short and long-term outcome.Endocrine · 2024Article
- Pheochromocytoma Diagnosed During First Trimester of Pregnancy.JCEM case reports · 2024Article
- Pheochromocytoma/Paraganglioma (PPGL): A Misdiagnosed Cause of Hypertension during Pregnancy.Case reports in obstetrics and gynecology · 2024Article
- Article
- Rates of Pheochromocytoma/Paraganglioma Screening in At-Risk Populations.The Journal of clinical endocrinology and metabolism · 2023Article
- A case of pheochromocytoma in pregnancy: A syndromic association.International journal of surgery case reports · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPhaeochromocytoma or paraganglioma (collectively known as PPGL) in pregnant women can lead to severe complications and death due to associated catecholamine excess. We aimed to identify factors associated with maternal and fetal outcomes in women with PPGL during pregnancy.
methodsWe did a multicentre, retrospective study of patients with PPGL and pregnancy between Jan 1, 1980, and Dec 31, 2019, in the International Pheochromocytoma and Pregnancy Registry and a systematic review of studies published between Jan 1, 2005, and Dec 27, 2019 reporting on at least five cases. The inclusion criteria were pregnancy after 1980 and PPGL before or during pregnancy or within 12 months post partum. Eligible patients from the retrospective study and systematic review were included in the analysis. Outcomes of interest were maternal or fetal death and maternal severe cardiovascular complications of catecholamine excess. Potential variables associated with these outcomes were evaluated by logistic regression.
findingsThe systematic review identified seven studies (reporting on 63 pregnancies in 55 patients) that met the eligibility criteria and were of adequate quality. A further 197 pregnancies in 186 patients were identified in the International Pheochromocytoma and Pregnancy Registry. After excluding 11 pregnancies due to potential overlap, the final cohort included 249 pregnancies in 232 patients with PPGL. The diagnosis of PPGL was made before pregnancy in 37 (15%) pregnancies, during pregnancy in 134 (54%), and after delivery in 78 (31%). Of 144 patients evaluated for genetic predisposition for phaeochromocytoma, 95 (66%) were positive. Unrecognised PPGL during pregnancy (odds ratio 27·0; 95% CI 3·5-3473·1), abdominal or pelvic tumour location (11·3; 1·5-1440·5), and catecholamine excess at least ten-times the upper limit of the normal range (4·7; 1·8-13·8) were associated with adverse outcomes. For patients diagnosed during pregnancy, α-adrenergic blockade therapy was associated with fewer adverse outcomes (3·6; 1·1-13·2 for no α-adrenergic blockade vs α-adrenergic blockade), whereas surgery during pregnancy was not associated with better outcomes (0·9; 0·3-3·9 for no surgery vs surgery).
interpretationUnrecognised and untreated PPGL was associated with a substantially higher risk of either maternal or fetal complications. Appropriate case detection and counselling for premenopausal women at risk for PPGL could prevent adverse pregnancy-related outcomes.
fundingUS National Institutes of Health.
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