Evidence map›Paper›PMID 33255213›Full record

ArticleMolecules (Basel, Switzerland)2020

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation.

Alexander Vogel, Mathias Bosse, Marcel Gauglitz, Sarah Wistuba, Peter Schmidt, Anette Kaiser, Vsevolod V Gurevich, Annette G Beck-Sickinger, Peter W Hildebrand, Daniel Huster

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander VogelInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.ORCID 0000-0001-8882-6410
Mathias BosseInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Marcel GauglitzInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Sarah WistubaInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Peter SchmidtInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Anette KaiserFaculty of Life Sciences, Institute of Biochemistry, University of Leipzig, Brüderstr. 34, D-04103 Leipzig, Germany.
Vsevolod V GurevichVanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0002-3950-5351
Annette G Beck-SickingerFaculty of Life Sciences, Institute of Biochemistry, University of Leipzig, Brüderstr. 34, D-04103 Leipzig, Germany.
Peter W HildebrandInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.ORCID 0000-0003-0063-1104
Daniel HusterInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.ORCID 0000-0002-3273-0943

Funding

Targeted Engineering of Designer Arrestins to Regulate Cell SignalingR35GM122491 · NIGMS · VANDERBILT UNIVERSITY · PI GUREVICH, VSEVOLOD V. · 2017 to 2021
$2.6M
Deutsche Forschungsgemeinschaft 421152132NIGMS NIH HHS R35 GM122491NIH HHS GM122491 and EY011500
6 · The paper itself

Abstract

We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation. First, the equilibrium dynamics of Y1R were studied using

Indexed as

Magnetic Resonance SpectroscopyMolecular Dynamics SimulationProtein ConformationDrug DiscoveryNuclear Magnetic Resonance, BiomolecularReceptors, Neuropeptide YRecombinant ProteinsStructure-Activity RelationshipReceptors, Neuropeptide YRecombinant ProteinsarrestinGPCRMD simulationmolecular switchNMR spectroscopystructural dynamics

Identifiers

PMID33255213
PMCPMC7727705

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.