Evidence map›Paper›PMID 33255391›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors.

Ronald Anderson, Annette J Theron, Helen C Steel, Jan G Nel, Gregory R Tintinger

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Design and Pharmacological Characterization of a Novel Antithrombotic P2YInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Exploring bias in platelet P2YBritish journal of pharmacology · 2024
    Review
  7. Stimulation of platelet P2YBritish journal of pharmacology · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ronald AndersonDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-5925-6452
Annette J TheronDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Helen C SteelDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0001-5899-4472
Jan G NelDepartment of Haematology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-4693-1092
Gregory R TintingerDepartment of Internal Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
University of Pretoria · ZANational Health Laboratory Service · ZA

Funding

National Health Laboratory Service of South Africa Research Trust 004-94693
6 · The paper itself

Abstract

This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5'-diphosphate (ADP, 100 µmol·L

Indexed as

adenosine 5′-diphosphatecytosolic calciumP2Y1/P2Y12 receptorsphosphatidylinositol 3-kinasephospholipase Cplatelets

Identifiers

PMID33255391
PMCPMC7760858
OpenAlexW3108826850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.