Evidence map›Paper›PMID 33258198›Full record

ReviewNeurogastroenterology and motility2021

Herbal medicines in functional dyspepsia-Untapped opportunities not without risks.

Kok-Ann Gwee, Gerald Holtmann, Jan Tack, Hidekazu Suzuki, Jinsong Liu, Yinglian Xiao, Min-Hu Chen, Xiaohua Hou, Deng-Chyang Wu, Clarissa Toh and 2 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05107999 naunknown statusnot on this map

Stigma and Efficacy of Zhizhu Kuanzhong Capsules Versus Doxepin in the Treatment of Refractory Functional Dyspepsia: a Randomized Controlled Trial

TypeinterventionalSponsorRenJi HospitalRan2021 to 2022Enrolled76ConditionsFunctional Gastrointestinal Disorders, Dyspepsia, Psychosomatic DisorderArmsZhizhu Kuanzhong capsules (ZZKZ), Doxepin Hydrochloride (Doxepin)
NCT05948215 nacompletednot on this map

Jing Si Herbal Tea in the Treatment of Dyspeptic Symptoms and Psychophysical Burden in Patients With Functional dyspepsia--a Double-blind, Randomized, Placebo-controlled Study

TypeinterventionalSponsorBuddhist Tzu Chi General HospitalRan2021 to 2021Enrolled26ConditionsFunctional Gastrointestinal Disorders, Healthy SubjectsArmsJing Si Herbal Tea Liquid Packet, Jing Si Herbal Tea Liquid Packet Placebo
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Double-blind, randomized, 8-week multicenter study of the efficacy and safety of STW 5-IIJGH open : an open access journal of gastroenterology and hepatology · 2024
    Article
  10. Article
  11. Article
  12. Efficacy and safety of the herbal formulaFrontiers in pharmacology · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kok-Ann GweeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and Gleneagles Hospital, Singapore City, Singapore.ORCID 0000-0002-4813-0053
Gerald HoltmannFaculty of Medicine & Faculty of Health & Behavioural Sciences, University of Queensland and Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.ORCID 0000-0002-0206-2358
Jan TackDepartment of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-3206-6704
Hidekazu SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Tokyo, Japan.ORCID 0000-0002-8994-6163
Jinsong LiuGastroenterology Department, Wuhan Union Hospital, Huazhong Science & Technology University, Wuhan, China.
Yinglian XiaoDivision of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-4278-8583
Min-Hu ChenDivision of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaohua HouDivision of Gastroenterology, Wuhan Union Hospital, Huazhong Science & Technology University, Wuhan, China.
Deng-Chyang WuDivision of Gastroenterology, Department of Internal Medicine, and Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Clarissa TohIndependent Researcher, Stomach, Liver & Bowel Centre, Gleneagles Hospital, Singapore City, Singapore.ORCID 0000-0001-9073-0100
Fang LuXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0000-0002-0570-7801
Xu-Dong TangXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0000-0001-9566-5782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContemporary treatments for functional dyspepsia have limitations. Herbal medicine has been suggested as adjunctive treatment. With growing scientific recognition and public interests, an in-depth review of this is timely. AIMS/PURPOSE: To evaluate the therapeutic potential and problems that may be associated with the adoption of herbal medicines in functional dyspepsia.

methodsWe reviewed the treatment landscape of functional dyspepsia and assessed the scientific community's interest in herbal medicine. Preclinical pharmacological and clinical trial data were reviewed for several herbal medicines available in the market. Challenges associated with adoption of herbal medicine in mainstream medicine were critically evaluated.

resultsWe found that herbal medicines frequently comprise a combination of herbs with multiple reported pharmacological effects on gastrointestinal motility and secretory functions, as well as cytoprotective and psychotropic properties. We identified a number of commercially available herbal products that have undergone rigorous clinical trials, involving large numbers of well-defined subjects, reporting both efficacy and safety for functional dyspepsia. Persisting concerns include lack of rigorous assessments for majority of products, toxicity, consistency of ingredients, dose standardizations, and quality control. We provide a quality framework for its evaluation.

conclusionsWe commend herbal medicine as a viable future option in managing functional dyspepsia. An attractive appeal of herbal medicine is the prospect to simultaneously target multiple pathophysiological mechanisms. Wider adoption and acceptance of herbal medicines in treatment algorithms of functional dyspepsia will require the application of the scientific rigor expected of chemical therapies, to all stages of their development and evaluation.

Indexed as

Gastrointestinal DiseasesHerbal MedicineHumansPhytotherapyPlant PreparationsPlant Preparationsfunctional dyspepsiagastrointestinal physiologyherbal medicinepharmacologytoxicitytreatment algorithms

Identifiers

PMID33258198
PMCPMC7900952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.