Evidence map›Paper›PMID 33270147›Full record

ReviewDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2021

[Adherence to anti-VEGF treatment-Considerations and practical recommendations].

Albrecht Lommatzsch, Nicole Eter, Christoph Ehlken, Ines Lanzl, Hakan Kaymak, Alexander K Schuster, Focke Ziemssen

Open access · hybridAbstract readReview
In one paragraph

Review in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Opportunities to Improve Management of Neovascular Age-related Macular Degeneration: Communication at Diagnosis and Beyond : Insights from the German nAMD Barometer Survey.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Real-world therapy and persistence of patients with neovascular age-related macular degeneration and diabetic retinopathy or diabetic macular edema: a German claims data analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  8. Article
  9. [The Hamburg register for intravitreal injection therapies (QIVOM)].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Albrecht LommatzschAugenzentrum am St. Franziskus-Hospital, Münster, Deutschland.
Nicole EterKlinik für Augenheilkunde, Universitätsklinikum Münster, Münster, Deutschland.
Christoph EhlkenKlinik für Ophthalmologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland.
Ines LanzlChiemsee Augen Tagesklinik, Prien, Deutschland.
Hakan KaymakMakula-Netzhaut-Zentrum, Düsseldorf-Oberkassel, Deutschland.
Alexander K SchusterAugenklinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Deutschland.
Focke ZiemssenDepartment für Augenheilkunde Tübingen, Universitäts-Augenklinik, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Deutschland. Focke.Ziemssen@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0002-3873-0581
Johannes Gutenberg University Mainz · DEOrtenau Klinikum · DESt. Franziskus Hospital · DEUniversitätsklinik für Augenheilkunde · CHUniversity Hospital Münster · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies have identified a lack of treatment adherence as an important factor that often conflicts with the necessary number of anti-VEGF injections and therefore a better functional result.

objectiveThis article discusses approaches and possible measures to reduce the risk of late and infrequent intravitreal injections leading to the major issue of undertreatment. MATERIAL AND

methodIn the course of an expert dialogue, relevant parameters of treatment adherence and variables were identified. Meaningful processes were structured and assigned to organizational areas.

resultsThe compilation of meaningful measures enables practitioners to optimize their own implementation in different areas. Regular monitoring measures can identify the extent of treatment interruption and discontinuation. For specific indicators (treatments per time interval, longest pause interval, minimum coverage per unit time, delay) an effect on the development of visual function was demonstrated. Organizational measures, training of teams and referring physicians, redundant and iterative information transfer to patients have been proven in the experience of experts. The firm integration of these processes into the structures is facilitated by working with checklists.

conclusionAn optimization of the processes is possible to improve the adherence and the functional results; however, interventional studies showing how adherence and persistence can be increased in the German treatment setting are still lacking.

Indexed as

Angiogenesis InhibitorsRanibizumabBevacizumabHumansIntravitreal InjectionsVascular Endothelial Growth Factor AAngiogenesis InhibitorsBevacizumabRanibizumabVascular Endothelial Growth Factor ABarriersIntravitreal injectionOptimizationOrganizationPersistence

Identifiers

PMID33270147
PMCPMC8342348
OpenAlexW3107301107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.