Evidence map›Paper›PMID 33270526›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial.

Fernando G Zampieri, Jonathan D Casey, Manu Shankar-Hari, Frank E Harrell, Michael O Harhay

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  9. Effect of tocilizumab, sarilumab, and baricitinib on mortality among patients hospitalized for COVID-19 treated with corticosteroids: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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  13. Trial
  14. A Bayesian re-analysis of the STRESS trial.American heart journal · 2026
    Trial
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  17. A Bayesian re-analysis of the DANFLU-1 trial.Human vaccines & immunotherapeutics · 2025
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernando G ZampieriResearch Institute, HCor-Hospital do Coração, São Paulo, Brazil.ORCID 0000-0001-9315-6386
Jonathan D CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine and.ORCID 0000-0002-0977-290X
Manu Shankar-HariDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-5338-2538
Frank E HarrellSchool of Immunology & Microbial Sciences, King's College London, London, United Kingdom; and.
Michael O HarhayPAIR (Palliative and Advanced Illness Research) Center Clinical Trials Methods and Outcomes Lab.ORCID 0000-0002-0553-674X

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9M
Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900k
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL153584NHLBI NIH HHS R00 HL141678
6 · The paper itself

Abstract

Most randomized trials are designed and analyzed using frequentist statistical approaches such as null hypothesis testing and

Indexed as

Bayes TheoremData Interpretation, StatisticalRandomized Controlled Trials as TopicHumansMortalityPositive-Pressure RespirationProportional Hazards ModelsRespiration, ArtificialRespiratory Distress SyndromeBayesiancritical careP valuerandomized trialsstatistical significance

Identifiers

PMID33270526
PMCPMC7924582

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.