Trial reportControlled clinical trials1987
The Cholesterol Lowering Atherosclerosis Study (CLAS): design, methods, and baseline results.
Trial report in Controlled clinical trials, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000599. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cholesterol-Lowering Atherosclerosis Study (CLAS)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Lipid-lowering for peripheral arterial disease of the lower limb.The Cochrane database of systematic reviews · 2007Pooled it
- Hypercholesterolemia screening. Does knowledge of blood cholesterol level affect dietary fat intake?Canadian family physician Medecin de famille canadien · 1998Trial
- The QUinapril Ischemic Event Trial (QUIET) design and methods: evaluation of chronic ACE inhibitor therapy after coronary artery intervention.Cardiovascular drugs and therapy · 1993Trial
- Women in the POSCH trial. Effects of aggressive cholesterol modification in women with coronary heart disease. The POSCH Group. Program on the Surgical Control of the Hyperlipidemias.Annals of surgery · 1992Trial
- Factors influencing the formation of new human coronary lesions: age, blood pressure, and blood cholesterol.American journal of public health · 1991 · on this mapTrial
- Precision and reproducibility of quantitative coronary angiography with applications to controlled clinical trials. A sampling study.The Journal of clinical investigation · 1989Trial
- Preclinical carotid atherosclerosis as an indicator of polyvascular disease: a narrative review.Annals of translational medicine · 2021Review
- NADFrontiers in physiology · 2020Review
- Niacin: an old lipid drug in a new NADJournal of lipid research · 2019Article
- Management and Prevention of Saphenous Vein Graft Failure: A Review.Cardiology and therapy · 2017Review
- Is There an Ideal Low-Density Lipoprotein Cholesterol Level? Confusion regarding Lipid Guidelines, Low-Density Lipoprotein Cholesterol Targets, and Medical Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Review
- Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.PloS one · 2016Article
- Carotid intima media thickness in type 2 diabetes mellitus with ischemic stroke.Indian journal of endocrinology and metabolism · 2013Article
- Problems and possible solutions for therapy with statins.The International journal of angiology : official publication of the International College of Angiology, Inc · 2013Review
- PCSK9 - A New and Potent Approach to Lowering Cholesterol.Oman medical journal · 2013Article
- Atherosclerosis: current status of prevention and treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2011Article
- Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.The Journal of clinical investigation · 2011Article
- Article
- Carotid vascular abnormalities in primary hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2009Article
- Thiazolidinediones and cardiovascular disease.Current atherosclerosis reports · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Cholesterol Lowering Atherosclerosis Study (CLAS) is a prospective, placebo-controlled, angiographic trial designed to test the hypothesis that aggressive lowering of LDL cholesterol with concomitant increase in HDL cholesterol will reverse or retard the atherosclerotic process. Specifically, CLAS was designed to determine whether combined therapy with colestipol plus niacin will produce clinically significant change in coronary, carotid, and femoral artery atherosclerosis and coronary bypass graft lesions. To this purpose, 188 subjects were randomized to diet plus drug or diet plus placebo. We report on methodological aspects of planning and evaluating this study, including the choice of the study population, procedures for recruitment, the experimental design including sample size considerations, methods for evaluating outcome, and methods for evaluating compliance to treatment. Comparison of baseline data indicated no significant differences between groups at the time of randomization. Subjects were predominantly male, Caucasian, 54 years of age, 20% above ideal weight, with normal blood pressure. The average age at bypass was 50 years. The average lipids were cholesterol (243 mg/dL), HDL (45 mg/dL), and LDL (168 mg/dL). Finally, the distribution of baseline coronary stenosis was equivalent between the two groups (average number of lesions per subject = 10.6).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.