Evidence map›Paper›PMID 33281142›Full record

ArticleThe Journal of veterinary medical science2021

Brain-derived neurotrophic factor is down regulated after bovine alpha-herpesvirus 5 infection in both wild-type and TLR3/7/9 deficient mice.

Daniele Gonçalves DA Silva, Iracema Luisa Quintino de Carvalho, Eliana Cristina de Brito Toscano, Beatriz Álvares da Silva Senra Santos, Bruna da Silva Oliveira, Marco Antônio Campos, Flávio Guimarães da Fonseca, Quezya Mendes Camargos, Gabriela Ferreira de Sousa, Marcelo Vidigal Caliari and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Daniele Gonçalves DA SilvaLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Iracema Luisa Quintino de CarvalhoDepartment of Microbiology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Eliana Cristina de Brito ToscanoLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Beatriz Álvares da Silva Senra SantosLaboratory of Animal Virology, Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Bruna da Silva OliveiraDepartment of Morphology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Marco Antônio CamposRené Rachou Institute, Fiocruz Minas, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Flávio Guimarães da FonsecaDepartment of Microbiology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Quezya Mendes CamargosLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Gabriela Ferreira de SousaLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Marcelo Vidigal CaliariLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Antônio Lúcio TeixeiraNeuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Texas Health Science Center at Houston, TX, 77054, USA.
Aline Silva de MirandaDepartment of Morphology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Milene Alvarenga RachidLaboratory of Cellular and Molecular Pathology, Department of General Pathology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Universidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BRInstituto Federal de Educação, Ciência e Tecnologia de Minas Gerais · BRThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophic factors have been implicated in the control of neuronal survival and plasticity in different brain diseases. Meningoencephalitis caused by bovine alpha-herpesvirus 5 (BoHV-5) infection is a frequent neurological disease of young cattle, being the involvement of apoptosis in the development of neuropathological changes frequently discussed in the literature. It's well known that Toll-like receptors (TLRs) can activate neuroinflammatory response and consequently lead to neuronal loss. However, there are no studies evaluating the expression of neurotrophic factors and their association with brain pathology and TLRs during the infection by BoHV-5. The current study aimed to analyze brain levels of neurotrophic factors along with neuropathological changes during acute infection by BoHV-5 in wild-type (WT) and TLR3/7/9 (TLR3/7/9

Indexed as

Herpesvirus 5, BovineAnimalsBrain-Derived Neurotrophic FactorCattleCattle DiseasesDown-RegulationHerpesviridae InfectionsMiceToll-Like Receptor 3Toll-Like Receptor 7Toll-Like Receptor 9Toll-Like ReceptorsBrain-Derived Neurotrophic FactorToll-Like Receptor 3Toll-Like Receptor 7Toll-Like Receptor 9Toll-Like Receptorsbovine herpesvirus 5brain-derived neurotrophic factortoll-like receptor

Identifiers

PMID33281142
PMCPMC7972877
OpenAlexW3111790689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.