Evidence map›Paper›PMID 33282184›Full record

ArticlePulmonary circulation

Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung.

Pritesh P Jain, Susumu Hosokawa, Mingmei Xiong, Aleksandra Babicheva, Tengteng Zhao, Marisela Rodriguez, Shamin Rahimi, Kiana Pourhashemi, Francesca Balistrieri, Ning Lai and 6 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  11. Review
  12. TRPC6, a therapeutic target for pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  13. Article
  14. Article
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  16. Therapeutic effects of SKF-96365 on murine allergic rhinitis induced by OVA.International journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Pritesh P JainSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Susumu HosokawaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Mingmei XiongSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Aleksandra BabichevaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Tengteng ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Marisela RodriguezSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Shamin RahimiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Kiana PourhashemiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Francesca BalistrieriSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Ning LaiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
Atul MalhotraSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, USA.
Daniela Valdez-JassoDepartment of Bioengineering, University of California, San Diego, CA, USA.
Patricia A ThistlethwaiteDepartment of Surgery, University of California, San Diego, CA, USA.
Ayako MakinoDivision of Endocrinology and Metabolism, University of California, San Diego, CA, USA.ORCID https://orcid.org/0000-0003-1259-8604
Jason X-J YuanSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA, USA.
University of California System · USUniversity of California San Diego · USTokyo Medical and Dental University · JP

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5M
Replacement of Small Animal Echocardiographic InstrumentationS10OD010417 · OD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ROSS, ROBERT SCOTT · 2012 to 2012
$371k
NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL146764NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R35 HL135807NHLBI NIH HHS T32 HL007444NHLBI NIH HHS U01 HL125208NIH HHS S10 OD010417
6 · The paper itself

Abstract

Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O

Indexed as

alveolar hypoxiacalcium ionisolated mouse lungL-type Ca2+ channeltransient receptor potential channel

Identifiers

PMID33282184
PMCPMC7691930
OpenAlexW3092416032

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.