Evidence map›Paper›PMID 33284381›Full record

SynthesisImmunogenetics2020

Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis.

Rohil Jawed, Mingming Zhang, Chan Wang, Shu-Han Yang, Peng Jiang, Qiuyuan Wu, Li Li, Weichang Chen, M Eric Gershwin, Ye Tian and 5 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Immunogenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Rohil JawedKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China.
Mingming ZhangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China.
Chan WangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China.
Shu-Han YangDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First Peoples Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China.
Peng JiangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China.
Qiuyuan WuKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China.
Li LiDepartment of Laboratory Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210009, China.
Weichang ChenDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, Suzhou, 215006, China.
M Eric GershwinDivision of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-Davis, Davis, CA, 95616, USA.
Ye TianDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Michael F SeldinDepartment of Biochemistry and Molecular Medicine, University of California At Davis School of Medicine, Davis, CA, USA.
Xiong MaDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Xiangdong LiuKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China. xiangdongliu@seu.edu.cn.
Zhe-Xiong LianDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First Peoples Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China. zxlian@scut.edu.cn.
Xingjuan ShiKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, 210096, China. xingjuanshi@seu.edu.cn.
Southeast University · CNGuangzhou First People's Hospital · CNUniversity of California, Davis · USGuangzhou Medical University · CNRenji Hospital · CNSecond Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Susceptibility to primary biliary cholangitis (PBC) is in part genetically determined. In our previous PBC genome-wide association study (GWAS) in 1118 Han Chinese PBC and 4036 controls, we noted that multiple SNPs in the runt-related transcription factor 3 (RUNX3) regions showed a nominally significant association. The tag SNP rs7529070 was genotyped using a TaqMan assay in a separately collected 1435 PBC and 3205 controls. A meta-analysis with a combined 2553 PBC and 7241 controls showed that rs7529070 is still nominally associated with PBC (p = 1.7 × 10

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAnimalsCase-Control StudiesCore Binding Factor Alpha 3 SubunitGenome-Wide Association StudyGenotypeHumansLiver Cirrhosis, BiliaryMicePrognosisReproducibility of ResultsCore Binding Factor Alpha 3 SubunitRunx3 protein, humanHan ChinesePrimary biliary cirrhosisRunt-related transcription factor 3SNP

Identifiers

PMID33284381
OpenAlexW3110787560

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.