Evidence map›Paper›PMID 33289416›Full record

ReviewJournal of the American Heart Association2020

Lipid Management in Patients Presenting With Acute Coronary Syndromes: A Review.

Bimmer E Claessen, Paul Guedeney, C Michael Gibson, Dominick J Angiolillo, Davide Cao, Norman Lepor, Roxana Mehran

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07685639 (Electronic Health Record Augmented LDL-Cholesterol Optimization and Control Via Active Lipid Engagement), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07685639 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Electronic Health Record Augmented LDL-Cholesterol Optimization and Control Via Active Lipid Engagement (EHR-LOCALE): A Quality Improvement Implementation Study

TypeinterventionalSponsorUniversity of AlbertaRan2026 to 2027Enrolled2,000ConditionsACS (Acute Coronary Syndrome), Hyperlipidemia, Dyslipidemia, Low-Density-Lipoprotein-cholesterol LevelArmsPharmacist-led lipid optimization pathway
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  10. 2025 Egyptian guidelines for the management of dyslipidemia.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Bimmer E ClaessenThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Paul GuedeneyThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
C Michael GibsonBeth Israel Deaconess Medical Center New York NY.
Dominick J AngiolilloDivision of Cardiology University of Florida College of Medicine Jacksonville FL.
Davide CaoThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Norman LeporCedars-Sinai Heart InstituteGeffen School of Medicine-University of Califonia - Los Angeles Los Angeles CA.
Roxana MehranThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Cardiovascular Institute of the South · USInserm · FRMount Sinai Beth Israel · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite many improvements in its prevention and management, acute coronary syndrome (ACS) remains a major cause of morbidity and mortality in the developed world. Lipid management is an important part of secondary prevention after ACS, but many patients currently remain undertreated and do not attain guideline-recommended levels of low-density lipoprotein cholesterol reduction. This review details the current state of evidence on lipid management in patients presenting with ACS, provides directions for identification of patients who may benefit from early escalation of lipid-lowering therapy, and discusses novel lipid-lowering medication that is currently under investigation in clinical trials. Moreover, a treatment algorithm aimed at attaining guideline-recommended low-density lipoprotein cholesterol levels is proposed. Despite important advances in the initial treatment and secondary prevention of ACS, ≈20% of ACS survivors experience a subsequent ischemic cardiovascular event within 24 months, and 5-year mortality ranges from 19% to 22%. Knowledge of the current state of evidence-based lipid management after ACS is of paramount importance to improve outcomes after ACS.

Indexed as

Acute Coronary SyndromeAdultAgedAged, 80 and overAnticholesteremic AgentsCholesterol, LDLCost-Benefit AnalysisDicarboxylic AcidsEicosapentaenoic AcidEzetimibeFatty AcidsFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipids8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acidALN-PCSAnticholesteremic AgentsCholesterol, LDLDicarboxylic AcidsEicosapentaenoic AcidEzetimibeFatty AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipidsPCSK9 InhibitorsPCSK9 protein, humanProprotein Convertase 9RNA, Small Interferingacute coronary syndromecardiovascularlipids

Identifiers

PMID33289416
PMCPMC7955383
OpenAlexW3110899797

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.