Evidence map›Paper›PMID 33292292›Full record

ArticleNutrition & metabolism2020

Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion in the second trimester: a case-control study in Chinese.

Mengyang Tang, Mingjuan Luo, Wenqian Lu, Rong Zhang, Wei Liang, Jianfen Gu, Xuemei Yu, Xueli Zhang, Cheng Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Chemokines in Gestational Diabetes Mellitus.Frontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mengyang TangThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Mingjuan LuoThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Wenqian LuThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Rong ZhangShanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Wei LiangDepartment of Endocrinology and Metabolism, University of Hong Kong Shenzhen Hospital, Shenzhen, China.
Jianfen GuDepartment of Endocrinology and Metabolism, University of Hong Kong Shenzhen Hospital, Shenzhen, China.
Xuemei YuThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Xueli ZhangThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Cheng HuThe Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. alfredhc@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-4314-2386
Xian Central Hospital · CNUniversity of Hong Kong - Shenzhen Hospital · CNShanghai Jiao Tong University · CN

Funding

National Science Foundation of China 81570713 and 91649112Outstanding Academic Leaders of Shanghai Health System 2017BR008the National Key Research and Development Project of China 2016YFC1304902
6 · The paper itself

Abstract

objectiveInflammation-related factors have been shown to play a significant role throughout pregnancy. In this study, we aimed to explore the relationships between selected inflammatory cytokines and gestational diabetes (GDM) in Chinese pregnant women. DESIGN AND

methodsThis was a 1:1 matched case-control study that included 200 pairs of subjects in the second trimester and 130 pairs of subjects in the third trimester. Serum levels of nerve growth factor (NGF), Interleukin-6 (IL-6), leptin, Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α) and Interleukin-1beta (IL-1β) were measured by enzyme immunoassay. The associations of these inflammatory factors with metabolic parameters were analysed.

resultsIn the second trimester, GDM patients had higher NGF levels and lower IL-8 levels than did normal controls (P < 0.001 and P = 0.015, respectively). However, in the third trimester, only lower leptin levels were observed in the GDM group (P = 0.031). Additionally, in the second trimester, NGF levels were not only positively associated with fasting, 1-h and 2-h glucose levels and the area under curve of glucose, but also positively related to insulin sensitivity and secretion, as suggested by fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment index of β-cell secretion (HOMA-β) (all P < 0.05). Moreover, IL-6 and leptin levels were positively correlated with HOMA-IR and HOMA-β, and TNF-α levels were positively related to HOMA-IR (all P < 0.05). Except for the relationships between NGF and HOMA-β and TNF-α and HOMA-IR, the other correlations still existed even after adjusting for confounding factors (all P < 0.05).

conclusionIn addition to the positive associations of IL-6 and leptin with insulin resistance and secretion, NGF was higher in the GDM patients and strongly linked to glucose metabolism, insulin resistance and pancreatic β cell function in Chinese pregnant women in the second trimester.

Indexed as

Gestational diabetesGlucose metabolismInflammatory cytokinesNerve growth factor

Identifiers

PMID33292292
PMCPMC7678221
OpenAlexW3106839814

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.