Evidence map›Paper›PMID 33293360›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons.

Angelina Lesnikova, Plinio Cabrera Casarotto, Senem Merve Fred, Mikko Voipio, Frederike Winkel, Anna Steinzeig, Hanna Antila, Juzoh Umemori, Caroline Biojone, Eero Castrén

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. [Research Progress on the Mechanisms of Visual Cortical Plasticity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Chondroitin 4-Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Angelina LesnikovaNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0003-4163-0044
Plinio Cabrera CasarottoNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0002-1090-4631
Senem Merve FredNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0003-1992-5014
Mikko VoipioNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0001-6881-7488
Frederike WinkelNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0002-2714-3912
Anna SteinzeigNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0001-7209-2811
Hanna AntilaNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0001-8317-4564
Juzoh UmemoriNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.ORCID 0000-0003-2595-7362
Caroline BiojoneNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland caroline.biojone@helsinki.fi eero.castren@helsinki.fi.ORCID 0000-0002-9674-4930
Eero CastrénNeuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland caroline.biojone@helsinki.fi eero.castren@helsinki.fi.ORCID 0000-0002-1402-2791
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV

Indexed as

AnimalsAntidepressive AgentsCells, CulturedCerebral CortexChondroitinases and Chondroitin LyasesMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicNeuronal PlasticityNeuronsParvalbuminsPhosphorylationProtein-Tyrosine KinasesReceptor-Like Protein Tyrosine Phosphatases, Class 2Antidepressive AgentsChondroitinases and Chondroitin LyasesMembrane GlycoproteinsNtrk2 protein, mouseParvalbuminsProtein-Tyrosine KinasesReceptor-Like Protein Tyrosine Phosphatases, Class 2Receptor, trkBBDNFchABCCSPGperineuronal netsPTPRSRPTPσ

Identifiers

PMID33293360
PMCPMC7880295
OpenAlexW3113306363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.