ArticleDrug design, development and therapy2020
Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
Article in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media.CPT: pharmacometrics & systems pharmacology · 2026Article
- Multi-Antibiotic Porous Systems for Tailored Drug Delivery in Dentistry: Formulation Strategy, Physicochemical Properties, and Release.Pharmaceutics · 2026Article
- Controlled Release Technologies for Diltiazem Hydrochloride: A Comprehensive Review of Solid Dosage Innovations.Pharmaceutics · 2025Review
- Extraction, Physicochemical Properties, and Biomedical Applications of Locust Bean Gum: A Comprehensive Review.Mini reviews in medicinal chemistry · 2025Review
- An Innovative Approach for Formulation of Rutin Tablets Targeted for Colon Cancer Treatment.AAPS PharmSciTech · 2023Article
- Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film.Pharmaceutics · 2023Article
- Wet heat energy for reaction of 2-hydroxy-1,2,3-propanetricarboxylic acid with caruba and applications for pharmaceutical dosage forms.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
methodsCentral design composite was adopted for the formulation and optimization of tablet formulations. The two gums have been selected as independent variables. The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T RESULTS AND DISCUSSION: It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet. FT-IR and DSC results confirm drug-polymer compatibility. Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables. After ANOVA analysis, the significant factors were considered for constrained optimization to get the optimized formula. The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties. The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the
conclusionThe results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.