Evidence map›Paper›PMID 33294175›Full record

ArticleAnnals of medicine and surgery (2012)2020

Vitamin D level and endogenous DNA damage in patients with cancers in Duhok city, KRG-Iraq.

Hishyar Azo Najeeb, Ramadhan Othman, Sherwan F Salih, Ayad Ahmad Mohammed, Qais Al Ismaeel

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Vitamin DThe American journal of clinical nutrition · 2025
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hishyar Azo NajeebDepartment of Medical Chemistry, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Ramadhan OthmanDepartment of Internal Medicine, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Sherwan F SalihDepartment of Medical Chemistry, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Ayad Ahmad MohammedDepartment of Surgery, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Qais Al IsmaeelDepartment of Biology, Histology and Anatomy, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
University of Duhok · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany clinical and pre-clinical studies suggested the protective effect of vitamin D against cancer development and cancer progression. Vitamin D deficiency is highly prevalent worldwide, and its link to DNA damage is worthy to study. It has been shown that vitamin D supplementation can reduce the risk of cancer with a favorable prognosis. Studies on DNA damage in different types of cancer and its link to plasma vitamin D has not been found in literature. PATIENTS AND

methodsIn this study we included 45 patients with different types of cancers and 35 healthy individuals as controls. The plasma vitamin D levels were measured in all participants. DNA damage levels of peripheral blood (mononuclear) cells in 45 newly diagnosed and untreated cancer patients and in 35 healthy individuals were measured using Alkaline Comet Assay technique.

resultsThe DNA damage observed in cancer patients was significantly higher than in healthy individuals. Interestingly, we have found a significant inverse correlation between the plasma levels of vitamin D and DNA damage in cancer patients (p < 0.0001) and in healthy individuals (p < 0.001).

conclusionThere is an inverse association between endogenous DNA damage and plasma vitamin D levels. Patients with vitamin D deficiency show highest levels of DNA damage suggesting that deficiency of vitamin D is probably one of the factors which increases the risk of cancer.

Indexed as

Cancer patientsEndogenous DNA damagePlasma vitamin DVitamin D deficiency

Identifiers

PMID33294175
PMCPMC7689000
OpenAlexW3100838459

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.