Evidence map›Paper›PMID 33294384›Full record

ArticleToxicology reports2021

Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. primary and community healthcare.

Konstantinos Farsalinos, Konstantinos Poulas, Dimitrios Kouretas, Apostolos Vantarakis, Michalis Leotsinidis, Dimitrios Kouvelas, Anca Oana Docea, Ronald Kostoff, Grigorios T Gerotziafas, Michael N Antoniou and 14 more

Abstract read
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Impact of COVID-19 Pandemic on Mental Health and Socioeconomic Aspects in Greece.International journal of environmental research and public health · 2023
    Article
  18. Article
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  20. Self-care in migrants with type 2 diabetes, during the COVID-19 pandemic.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Konstantinos FarsalinosLaboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, Panepistimiopolis, 26500, Greece.
Konstantinos PoulasLaboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, Panepistimiopolis, 26500, Greece.
Dimitrios KouretasDepartment of Biochemistry and Biotechnology, University of Thessaly, Larisa, 41500, Greece.
Apostolos VantarakisSchool of Medicine, University of Patras, Panepistimiopolis, 26500, Greece.
Michalis LeotsinidisLab. of Public Health, Medical School, University of Patras, University Campus, 26504, Greece.
Dimitrios KouvelasLaboratory of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania.
Ronald KostoffSchool of Public Policy, Georgia Institute of Technology, Gainesville, VA, 20155, USA.
Grigorios T GerotziafasSorbonne Université, INSERM, UMR_S 938, Group de recherche « Cancer-Hemostasis-Angiogenesis », Centre de recherche Saint-Antoine, CRSA, Centre de Thrombose, Tenon-Saint Antoine, University Hospitals, Assistance publique Hôpitaux de Paris, France.
Michael N AntoniouGene Expression and Therapy Group, King's College London, Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
Riccardo PolosaDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97 95131, Catania, Italy.
Anastastia BarbouniSchool of Public Health, University of West Attica, L Alexandras 196A, Athens, 11521, Greece.
Vassiliki YiakoumakiDepartment of History, Archaeology and Social Anthropology, University of Thessaly, 38221, Volos, Greece.
Theodoros V GiannouchosPharmacotherapy Outcomes Research Center, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Pantelis G BagosDepartment of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, 35100, Greece.
George LazopoulosDepartment of Cardiac Surgery, University Hospital of Heraklion, Crete, Greece.
Boris N IzotovDepartment of Analytical Toxicology, Pharmaceutical Chemistry and Pharmacognosy, Sechenov University, 119991, Moscow, Russia.
Victor A TutelyanFederal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation.
Michael AschnerDepartment of Molecular Pharmacology, Albert Eisntein College of Medicine, 1300 Morris Park Avenue Bronx, NY, 10461, USA.
Thomas HartungCenter for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Heather M WallaceInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Félix CarvalhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Jose L DomingoLaboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Catalonia, Spain.
Aristides TsatsakisDepartment of Analytical Toxicology, Pharmaceutical Chemistry and Pharmacognosy, Sechenov University, 119991, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 pandemic mitigation strategies are mainly based on social distancing measures and healthcare system reinforcement. However, many countries in Europe and elsewhere implemented strict, horizontal lockdowns because of extensive viral spread in the community which challenges the capacity of the healthcare systems. However, strict lockdowns have various untintended adverse social, economic and health effects, which have yet to be fully elucidated, and have not been considered in models examining the effects of various mitigation measures. Unlike commonly suggested, the dilemma is not about health vs wealth because the economic devastation of long-lasting lockdowns will definitely have adverse health effects in the population. Furthermore, they cannot provide a lasting solution in pandemic containment, potentially resulting in a vicious cycle of consecutive lockdowns with in-between breaks. Hospital preparedness has been the main strategy used by governments. However, a major characteristic of the COVID-19 pandemic is the rapid viral transmission in populations with no immunity. Thus, even the best hospital system could not cope with the demand. Primary, community and home care are the only viable strategies that could achieve the goal of pandemic mitigation. We present the case example of Greece, a country which followed a strategy focused on hospital preparedness but failed to reinforce primary and community care. This, along with strategic mistakes in epidemiological surveillance, resulted in Greece implementing a second strict, horizontal lockdown and having one of the highest COVID-19 death rates in Europe during the second wave. We provide recommendations for measures that will reinstate primary and community care at the forefront in managing the current public health crisis by protecting hospitals from unnecessary admissions, providing primary and secondary prevention services in relation to COVID-19 and maintaining population health through treatment of non-COVID-19 conditions. This, together with more selective social distancing measures (instead of horizontal lockdowns), represents the only viable and realistic long-term strategy for COVID-19 pandemic mitigation.

Indexed as

COVID-19 pandemicHorizontal lockdownsHospital preparednessPrimary care

Identifiers

PMID33294384
PMCPMC7713637

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.