Evidence map›Paper›PMID 33296276›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Clinical and molecular characterization of the R751L-CFTR mutation.

Iram J Haq, Mike Althaus, Aaron Ions Gardner, Hui Ying Yeoh, Urjita Joshi, Vinciane Saint-Criq, Bernard Verdon, Jennifer Townshend, Christopher O'Brien, Mahfud Ben-Hamida and 7 more

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Precision Medicine Based on CFTR Genotype for People with Cystic Fibrosis.Pharmacogenomics and personalized medicine · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Iram J HaqTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0002-5795-0440
Mike AlthausInstitute for Functional Gene Analytics, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany.
Aaron Ions GardnerTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Hui Ying YeohCellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Urjita JoshiCellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Vinciane Saint-CriqBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Bernard VerdonBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Jennifer TownshendPaediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Christopher O'BrienPaediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Mahfud Ben-HamidaDepartment of Paediatrics, West Cumberland Hospital, Whitehaven, United Kingdom.
Matthew ThomasPaediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Stephen BourkeRespiratory Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-2370-6551
Peter van der SluijsCellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Ineke BraakmanCellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Chris WardTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Michael A GrayBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Malcolm BrodlieTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-4591-8299

Funding

Medical Research Council MR/M008797/1Medical Research Council (MRC) MR/M008797/1Wellcome TrustWellcome Trust (Wellcome) 203520/Z/16/Z
6 · The paper itself

Abstract

Cystic fibrosis (CF) arises from mutations in the CF transmembrane conductance regulator (

Indexed as

BronchiCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsMutation, MissenseAmino Acid SubstitutionAnimalsFemaleHumansMaleSodium ChlorideXenopus laevisCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorSodium ChlorideCFTR mutationscystic fibrosisprimary airway epithelial cellsR751L

Identifiers

PMID33296276
PMCPMC8476205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.