Evidence map›Paper›PMID 33296550›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Frailty and aging-associated syndromes in lung transplant candidates and recipients.

Joanna M Schaenman, Joshua M Diamond, John R Greenland, Cynthia Gries, Cassie C Kennedy, Amit D Parulekar, Dmitry Rozenberg, Jonathan P Singer, Lianne G Singer, Laurie D Snyder and 1 more

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  11. Article
  12. Review
  13. Venous thromboembolism following lung transplantation.World journal of transplantation · 2025
    Review
  14. Article
  15. Article
  16. Key Associations Found in the Struggle With Sleep in Lung Transplant Recipients.Progress in transplantation (Aliso Viejo, Calif.) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Joanna M SchaenmanDepartment of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1174-3961
Joshua M DiamondDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
John R GreenlandDepartment of Medicine, San Francisco VA Health Care System, University of California, San Francisco, California, USA.ORCID 0000-0003-1422-8367
Cynthia GriesDepartment of Medicine, AdventHealth Transplant Institute, Orlando, Florida, USA.
Cassie C KennedyDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Amit D ParulekarDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-4828-4041
Dmitry RozenbergDepartment of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8786-9152
Jonathan P SingerDepartment of Medicine, San Francisco VA Health Care System, University of California, San Francisco, California, USA.ORCID 0000-0003-0224-7472
Lianne G SingerDepartment of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Laurie D SnyderDepartment of Medicine, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-5962-2184
Sangeeta BhoradeMedical Affairs-Pulmonary, Veracyte Inc, South San Francisco, California, USA.
University Health Network · CAUniversity of California, San Francisco · USDuke University · USMayo Clinic · USMiami Transplant Institute · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · USVanderbilt University · USVeracyte (United States) · US

Funding

Telomere Dysfunction as a cause of Chronic Lung Allograft DysfunctionR01HL151552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2024
$1.6M
Exploring the Unmeasured Risk and Treating the Untreated Prognostic Factor: Towards Candidate Optimization in Heart and Lung TransplantK23HL128859 · NHLBI · MAYO CLINIC ROCHESTER · PI KENNEDY, CASSIE COLLEEN · 2016 to 2020
$854k
Evaluation of Epigenetic Markers of Biologic Age to Predict Adverse Outcomes after TransplantationR21AG055879 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHAENMAN, JOANNA M · 2018 to 2019
$429k
Cytomegalovirus Immune Responses in Chronic Lung Allograft Dysfunction PathogenesisI01CX002011 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2025
–
CSRD VA I01 CX002011NHLBI NIH HHS K23 HL128859NHLBI NIH HHS R01 HL151552NIA NIH HHS R21 AG055879
6 · The paper itself

Abstract

Many lung transplant candidates and recipients are older and frailer compared to previous eras. Older patients are at increased risk for pre- and posttransplant mortality, but this risk is not explained by numerical age alone. This manuscript represents the product of the American Society of Transplantation (AST) conference on frailty. Experts in the field reviewed the latest published research on assessment of elderly and frail lung transplant candidates. Physical frailty, often defined as slowness, weakness, low physical activity, shrinking, and exhaustion, and frailty evaluation is an important tool for evaluation of age-associated dysfunction. Another approach is assessment by cumulative deficits, and both types of frailty are common in lung transplant candidates. Frailty is associated with death or delisting before transplant, and may be associated with posttransplant mortality. Sarcopenia, cognitive dysfunction, depression, and nutrition are other important components for patient evaluation. Aging-associated inflammation, telomere dysfunction, and adaptive immune system senescence may also contribute to frailty. Developing tools for frailty assessment and interventions holds promise for improving patient outcomes before and after lung transplantation.

Indexed as

FrailtyLung TransplantationSarcopeniaAgedAgingFrail ElderlyHumansSyndromeclinical decision-makingclinical research / practicecomplication: medical / metabolicgeriatricsimmunobiologylung biologylung transplantation / pulmonologyrecipient selectionrisk assessment / risk stratificationtranslational research / science

Identifiers

PMID33296550
PMCPMC8178173
OpenAlexW3111417632

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.