Evidence map›Paper›PMID 33298541›Full record

ArticleJournal of virology2021

Stabilizing the HIV-1 envelope glycoprotein State 2A conformation.

Dani Vézina, Shang Yu Gong, William D Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B Smith, Marzena Pazgier and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dani VézinaCentre de Recherche du CHUM, Montreal, QC, Canada.
Shang Yu GongCentre de Recherche du CHUM, Montreal, QC, Canada.
William D TolbertInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Shilei DingCentre de Recherche du CHUM, Montreal, QC, Canada.
Dung NguyenInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Jonathan RichardCentre de Recherche du CHUM, Montreal, QC, Canada.
Gabrielle Gendron-LepageCentre de Recherche du CHUM, Montreal, QC, Canada.
Bruno MelilloDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Amos B SmithDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Marzena PazgierInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Andrés FinziCentre de Recherche du CHUM, Montreal, QC, Canada andres.finzi@umontreal.ca.ORCID https://orcid.org/0000-0002-4992-5288
Centre Hospitalier de l’Université de Montréal · CAUniformed Services University of the Health Sciences · USUniversity of Pennsylvania · US

Funding

Understanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01GM056550 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CAMERON F · 1997 to 2018
$31.2M
Computational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4M
Exploring HIV-1 Env open conformations for therapeutic interventionR01AI150322 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Andres Finzi, James B Munro · 2020 to 2026
$4.2M
Unlocking Envelope: A New Strategy for a Functional Cure Through Antibody-Dependent Cell-Mediated CytotoxicityR01AI129769 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2017 to 2021
$2.3M
Structural Targeting of Potentially Protective gp120 Epitopes in the C1/C2 RegionR01AI116274 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2016 to 2019
$1.5M
NIAID NIH HHS R01 AI116274NIAID NIH HHS R01 AI129769NIAID NIH HHS R01 AI150322NIAID NIH HHS U01 AI150741NIGMS NIH HHS P01 GM056550
6 · The paper itself

Abstract

The HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)

Identifiers

PMID33298541
PMCPMC8092833
OpenAlexW3112431144

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.