Evidence map›Paper›PMID 33300990›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2021

Appetite-Regulating Hormones Are Reduced After Oral Sucrose vs Glucose: Influence of Obesity, Insulin Resistance, and Sex.

Alexandra G Yunker, Shan Luo, Sabrina Jones, Hilary M Dorton, Jasmin M Alves, Brendan Angelo, Alexis DeFendis, Trevor A Pickering, John R Monterosso, Kathleen A Page

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexandra G YunkerDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Shan LuoDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sabrina JonesDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hilary M DortonDiabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jasmin M AlvesDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Brendan AngeloDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexis DeFendisDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Trevor A PickeringDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
John R MonterossoDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Kathleen A PageDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$9.1M
NCATS NIH HHS UL1 TR001855NIDDK NIH HHS R01 DK102794
6 · The paper itself

Abstract

contextFructose compared to glucose has adverse effects on metabolic function, but endocrine responses to oral sucrose vs glucose is not well understood.

objectiveWe investigated how oral sucrose vs glucose affected appetite-regulating hormones, and how biological factors (body mass index [BMI], insulin sensitivity, sex) influence endocrine responses to these 2 types of sugar.

designSixty-nine adults (29 men; 23.22 ± 3.74 years; BMI 27.03 ± 4.96 kg/m2) completed the study. On 2 occasions, participants consumed 300-mL drinks containing 75 g of glucose or sucrose. Blood was sampled at baseline, 10, 35, and 120 minutes post drink for plasma glucose, insulin, glucagon-like peptide (GLP-1)(7-36), peptide YY (PYY)total, and acyl-ghrelin measures. Hormone levels were compared between conditions using a linear mixed model. Interaction models were performed, and results were stratified to assess how biological factors influence endocrine responses.

resultsSucrose vs glucose ingestion provoked a less robust rise in glucose (P < .001), insulin (P < .001), GLP-1 (P < .001), and PYY (P = .02), whereas acyl-ghrelin suppression was similar between the sugars. We found BMI status by sugar interactions for glucose (P = .01) and PYY (P = .03); obese individuals had smaller increases in glucose and PYY levels after consuming sucrose vs glucose. There were interactions between insulin sensitivity and sugar for glucose (P = .003) and insulin (P = .04), and a sex by sugar interaction for GLP-1 (P = .01); men demonstrated smaller increases in GLP-1 in response to oral sucrose vs glucose.

conclusionSucrose is less efficient at signaling postprandial satiation than glucose, and biological factors influence differential hormone responses to sucrose vs glucose consumption.

Indexed as

Administration, OralAdolescentAdultAppetiteAppetite RegulationBlood GlucoseBody Mass IndexDown-RegulationEatingFemaleGhrelinGlucagon-Like Peptide 1GlucoseGlucose Tolerance TestHumansInsulin Resistanceacyl-ghrelinBlood GlucoseGhrelinGlucagon-Like Peptide 1GlucosePeptide YYSucroseglucoseinsulin resistanceobesityperipherysexsucrose

Identifiers

PMID33300990
PMCPMC7947782
OpenAlexW3112440867

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.