Evidence map›Paper›PMID 33301009›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study.

Edgar J Gallardo, Derrick A Gray, Richard L Hoffman, Brandon A Yates, Ranjani N Moorthi, Andrew R Coggan

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Trial
  6. Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
    Trial
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  16. The relationship between voluntary and electrically evoked muscle contractile properties in young women.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025
    Article
  17. Article
  18. Nitric oxide and skeletal muscle contractile function.Nitric oxide : biology and chemistry · 2022
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Edgar J GallardoDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis.
Derrick A GrayDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis.
Richard L HoffmanDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis.
Brandon A YatesDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis.
Ranjani N MoorthiDepartment of Internal Medicine, School of Medicine, Indiana University Purdue University Indianapolis.
Andrew R CogganDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis.
Indiana University – Purdue University Indianapolis · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Resource CoreP30AR072581 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe · 2017 to 2026
$8.3M
Longitudinal Assessment of Skeletal Muscle Physiology in Dialysis PatientsK23DK102824 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOORTHI, RANJANI N. · 2015 to 2019
$892k
THE INORGANIC NITRATE FOR EXERCISE IN HEART FAILURE (INIX-HF) TRIALR34HL138253 · NHLBI · WASHINGTON UNIVERSITY · PI COGGAN, ANDREW R, PETERSON, LINDA RUTH · 2017 to 2019
$701k
Dietary Nitrate and Muscle Power with AgingR21AG053606 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI COGGAN, ANDREW R · 2018 to 2019
$433k
NCATS NIH HHS UL1 TR002529NHLBI NIH HHS R34 HL138253NIAMS NIH HHS P30 AR072581NIA NIH HHS R21 AG053606NIDDK NIH HHS K23 DK102824
6 · The paper itself

Abstract

We have recently demonstrated that dietary nitrate, a source of nitric oxide (NO) via the nitrate → nitrite → NO enterosalivary pathway, can improve muscle contractility in healthy older men and women. Nitrate ingestion has also been shown to reduce blood pressure in some, but not all, studies of older individuals. However, the optimal dose for eliciting these beneficial effects is unknown. A pilot randomized, double-blind, placebo-controlled crossover study was therefore performed to determine the effects of ingesting 3.3 mL/kg of concentrated beetroot juice containing 0, 200, or 400 µmol/kg of nitrate in 9 healthy older subjects (mean age 70 ± 1 years). Maximal knee extensor power (Pmax) and speed (Vmax) were measured ~2.5 hours after nitrate ingestion using isokinetic dynamometry. Blood pressure was monitored periodically throughout each study. Pmax (in W/kg) was higher (p < .05) after the lower dose (3.9 ± 0.4) compared to the placebo (3.7 ± 0.4) or higher dose (3.7 ± 0.4). Vmax (in rad/s) also tended to be higher (p = .08) after the lower dose (11.9 ± 0.7) compared to the placebo (10.8 ± 0.8) or higher dose (11.2 ± 0.8). Eight out of 9 subjects achieved a higher Pmax and Vmax after the lower versus the higher dose. These dose-related changes in muscle contractility generally paralleled changes in breath NO levels. No significant changes were found in systolic, diastolic, or mean arterial blood pressure. A lower dose of nitrate increases muscle speed and power in healthy older individuals, but these improvements are lost at a higher dose. Blood pressure, on the other hand, is not reduced even with a higher dose.

Indexed as

Beta vulgarisDose-Response Relationship, DrugNitric OxideAgedBlood PressureBreath TestsDietary SupplementsDouble-Blind MethodFemaleFruit and Vegetable JuicesHealthy VolunteersHumansMaleMonitoring, PhysiologicMuscle ContractionNitratesNitratesNitric OxidePhytochemicals3-NitrotyrosineIsokinetic dynamometryNitric oxideNitrite

Identifiers

PMID33301009
PMCPMC8011703
OpenAlexW3112693409

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.