Evidence map›Paper›PMID 33301326›Full record

ArticleMolecular pharmaceutics2021

Comparison of Amorphous Solid Dispersions of Spironolactone Prepared by Spray Drying and Electrospinning: The Influence of the Preparation Method on the Dissolution Properties.

Edina Szabó, Petra Záhonyi, Dániel Brecska, Dorián L Galata, Lilla A Mészáros, Lajos Madarász, Kristóf Csorba, Panna Vass, Edit Hirsch, Joanna Szafraniec-Szczęsny and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Edina SzabóDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Petra ZáhonyiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Dániel BrecskaDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Dorián L GalataDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Lilla A MészárosDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Lajos MadarászDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Kristóf CsorbaDepartment of Automation and Applied Informatics, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Panna VassDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Edit HirschDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Joanna Szafraniec-SzczęsnyDepartment of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
István CsontosDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Attila FarkasDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Guy Van denMooterDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Zsombor K NagyDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.ORCID 0000-0003-2651-7756
György MarosiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Budapest University of Technology and Economics · HUKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research aimed to compare two solvent-based methods for the preparation of amorphous solid dispersions (ASDs) made up of poorly soluble spironolactone and poly(vinylpyrrolidone-

Indexed as

Calorimetry, Differential ScanningChemistry, PharmaceuticalCrystallizationDesiccationDrug CompoundingPolymersPowder DiffractionPowdersPyrrolidinesSolubilitySolventsSpironolactoneSpray DryingVinyl CompoundsX-Ray DiffractionPolymerspoly(vinylpyrrolidone-co-vinyl-acetate)PowdersPyrrolidinesSolventsSpironolactoneVinyl Compoundsamorphous solid dispersiondissolutionelectrospinningscale-upspray drying

Identifiers

PMID33301326
PMCPMC7788570
OpenAlexW3113091268

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.