Evidence map›Paper›PMID 33304139›Full record

ArticleSaudi journal of biological sciences2020

Down-regulation of hepatic G-6-Pase expression in hyperglycemic rats: Intervention with biogenic gold nanoconjugate.

Sengani Manimegalai, Shahid Mahboob, Khalid A Al-Ghanim, Fahad Al-Misned, Marimuthu Govindarajan, Krishnan Anbarasu, Vijayarangan Devi Rajeswari

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sengani ManimegalaiDepartment of Bio-Medical Sciences, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
Shahid MahboobDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Khalid A Al-GhanimDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Fahad Al-MisnedDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Marimuthu GovindarajanUnit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
Krishnan AnbarasuDepartment of Bioinformatics, School of Life Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai 600 117, Tamil Nadu, India.
Vijayarangan Devi RajeswariDepartment of Bio-Medical Sciences, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
King Saud University · SAVellore Institute of Technology University · INAnnamalai University · INVels University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic diabetes extensively complicates the glucose metabolism to onset and progress the complication. Concurrently, several contemporary medicines, especially organo-metallic formulations, are emerging to treat hyperglycemia. The current study aims to emphasize the gold nanoparticles (GNPs) potential for glucose metabolism regulation in Streptozotocin (STZ) induced diabetes. Quantitative real-time polymerase chain reaction (RT-PCR) was carried out to detect the mRNA expression of Glucose transporters 2 (GLUT2), Glucokinase (GK) and Glucose 6 Phosphatase (G-6-Pase). The study shows remarkable results such as the prognostic effect of GNPs in reinforcing the repression of enzyme complex G-6-Pase about 13.3-fold when compared to diabetes control. Also, molecular docking studies showed significant inhibition of G-6-Pase by the terpenoid ligands with alpha and beta amyrin from leaf extract of

Indexed as

Couroupita guianensisDiabetesGlucose 6 phosphataseGold nanoparticlesQuantitative RT-PCR

Identifiers

PMID33304139
PMCPMC7715047
OpenAlexW3088688942

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.