Evidence map›Paper›PMID 33305206›Full record

ArticleCJC open2020

Effectiveness and Safety of Statin Therapy in Children: A Real-World Clinical Practice Experience.

Rae-Ellen W Kavey, Cedric Manlhiot, Kyle Runeckles, Tanveer Collins, Samuel S Gidding, Matthew Demczko, Sarah Clauss, Ashraf S Harahsheh, Michele Mietus-Syder, Michael Khoury and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Statins in Children, an Update.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Rae-Ellen W KaveyPreventive Cardiology-Lipid Clinic, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, New York, USA.
Cedric ManlhiotThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Kyle RunecklesThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Tanveer CollinsThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Samuel S GiddingPreventive Cardiology-Lipid Clinic, Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
Matthew DemczkoPreventive Cardiology-Lipid Clinic, Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
Sarah ClaussPreventive Cardiology Program-Lipid Clinic, Children's National Hospital, George Washington University School of Medicine and Health, Washington, DC, USA.
Ashraf S HarahshehPreventive Cardiology Program-Lipid Clinic, Children's National Hospital, George Washington University School of Medicine and Health, Washington, DC, USA.
Michele Mietus-SyderPreventive Cardiology Program-Lipid Clinic, Children's National Hospital, George Washington University School of Medicine and Health, Washington, DC, USA.
Michael KhouryPediatric Lipid Clinic, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Nicolas MadsenPediatric Lipid Clinic, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Brian W McCrindleThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAGeorge Washington University Hospital · USCincinnati Children's Hospital Medical Center · USDuPont (United States) · USUniversity of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStatin use for hypercholesterolemia in children is predominantly reported from short-term clinical trials. In this study, we assess the efficacy and safety of statin treatment in clinical pediatric practice.

methodsRecords of all patients who began statin treatment at age <18 years and remained on statins for >6 months from 5 pediatric lipid clinics were reviewed. Information at baseline and from all clinic evaluations after statin initiation was recorded, including lipid measurements, statin drug/dose, safety measures (anthropometry, hepatic enzymes, creatine kinase levels), and symptoms. Lipid changes on statin therapy were assessed from baseline to 6 ± 3 months and from 6 ± 3 months to last follow-up with a mixed-effects model, using piecewise linear splines to describe temporal changes, controlling for repeated measures, sex, and age.

resultsThere were 289 patients with median low-density lipoprotein cholesterol (LDL-C) of 5.3 mmol/L (interquartile range [IQR]:4.5-6.5) and mean age of 12.4 ± 2.9 years at statin initiation. Median duration of therapy was 2.7 years (IQR: 1.6-4.5) with 95% on statins at last evaluation. There were significant decreases in total cholesterol, LDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C) from baseline to 6 ± 3 months (

conclusionsIn real-world clinical practice, intermediate-term statin treatment is effective and safe in children and adolescents with severe LDL-C elevation.

Identifiers

PMID33305206
PMCPMC7710927
OpenAlexW3034053585

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.